P2RY1 - P2Y purinoceptor 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
P2RY1 »  P2Y purinoceptor 1  (P2Y1)
 
Protein also known as:  Purinergic receptor.
Gene name:  P2RY1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 77 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.  
2
  • UniProtKB
GO molecular function 
A1 adenosine receptor bindingdefinition[GO:0031686] silver  
1
  • Ortholog Compara
ADP bindingdefinition[GO:0043531] silver  
1
  • Ortholog Compara
ADP-activated nucleotide receptor activitydefinition[GO:0045032] silver  
1
  • Ortholog Compara
ATP bindingdefinition[GO:0005524] silver  
1
  • Ortholog Compara
ATP-activated nucleotide receptor activitydefinition[GO:0045031]  
1
  • Ortholog Curator
G-protein coupled purinergic nucleotide receptor activitydefinition[GO:0045028]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Receptor activitydefinition[GO:0004872]  
1
  • PINC
Scaffold protein bindingdefinition[GO:0097110]  
1
  • Ortholog Curator
GO biological process 
Adenosine receptor signaling pathwaydefinition[GO:0001973] silver  
1
  • Ortholog Compara
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193] silver  
1
  • Ortholog Compara
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Eating behaviordefinition[GO:0042755] silver  
1
  • Ortholog Compara
G-protein coupled purinergic nucleotide receptor signaling pathwaydefinition[GO:0035589] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • Ortholog Curator
Negative regulation of bindingdefinition[GO:0051100] silver  
1
  • Ortholog Compara
Negative regulation of norepinephrine secretiondefinition[GO:0010700] silver  
1
  • Ortholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200] silver  
1
  • InterPro 2 GO
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • Ortholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • Ortholog Curator
Positive regulation of hormone secretiondefinition[GO:0046887] silver  
1
  • Ortholog Compara
Positive regulation of inositol trisphosphate biosynthetic processdefinition[GO:0032962] silver  
1
  • Ortholog Compara
Positive regulation of ion transportdefinition[GO:0043270] silver  
1
  • Ortholog Compara
Positive regulation of penile erectiondefinition[GO:0060406] silver  
1
  • Ortholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Protein localization to plasma membranedefinition[GO:0072659]  
1
  • Ortholog Curator
Regulation of receptor activitydefinition[GO:0010469] silver  
1
  • Ortholog Compara
Regulation of vasodilationdefinition[GO:0042312] silver  
1
  • Ortholog Compara
Relaxation of muscledefinition[GO:0090075] silver  
1
  • InterPro 2 GO
Response to growth factordefinition[GO:0070848] silver  
1
  • Ortholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
1
  • Ortholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
1
  • Ortholog Compara
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+5028  
According to Reactome, this protein belongs to the following pathways:
ADP signalling through P2Y purinoceptor 1  REACT_19140  
G alpha (q) signalling events  REACT_18283  
P2Y receptors  REACT_18289  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2RY1
GenomeRNAi: 5028
PRO: PR:P47900
Chemistry
GuidetoPHARMACOLOGY: 323