P2RY1 - P2Y purinoceptor 1 - human protein (Function)
 
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P2RY1 »  P2Y purinoceptor 1  (P2Y1)
 
Protein also known as:  Purinergic receptor.
Gene name:  P2RY1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.  
1
  • CuratedUniProtKB
GO molecular function 
A1 adenosine receptor bindingdefinition[GO:0031686] silver  
  • IEAOrtholog Compara
ADP bindingdefinition[GO:0043531] silver  
  • IEAOrtholog Compara
ADP-activated nucleotide receptor activitydefinition[GO:0045032] silver  
  • IEAOrtholog Compara
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
ATP-activated nucleotide receptor activitydefinition[GO:0045031] silver  
  • IEAOrtholog Compara
G-protein coupled purinergic nucleotide receptor activitydefinition[GO:0045028]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Scaffold protein bindingdefinition[GO:0097110]  
  • ISSOrtholog Curator
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193] silver  
  • IEAOrtholog Compara
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Eating behaviordefinition[GO:0042755] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • ISSOrtholog Curator
Negative regulation of bindingdefinition[GO:0051100] silver  
  • IEAOrtholog Compara
Negative regulation of norepinephrine secretiondefinition[GO:0010700] silver  
  • IEAOrtholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200] silver  
  • IEAInterPro 2 GO
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
  • ISSOrtholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
  • ISSOrtholog Curator
Positive regulation of hormone secretiondefinition[GO:0046887] silver  
  • IEAOrtholog Compara
Positive regulation of inositol trisphosphate biosynthetic processdefinition[GO:0032962] silver  
  • IEAOrtholog Compara
Positive regulation of ion transportdefinition[GO:0043270] silver  
  • IEAOrtholog Compara
Positive regulation of penile erectiondefinition[GO:0060406] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Protein localization to plasma membranedefinition[GO:0072659]  
  • ISSOrtholog Curator
Regulation of receptor activitydefinition[GO:0010469] silver  
  • IEAOrtholog Compara
Regulation of vasodilationdefinition[GO:0042312] silver  
  • IEAOrtholog Compara
Relaxation of muscledefinition[GO:0090075] silver  
  • IEAInterPro 2 GO
Response to growth factordefinition[GO:0070848] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+5028  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2RY1
GenomeRNAi: 5028
PRO: PR:P47900
Chemistry
GuidetoPHARMACOLOGY: 323