AVPR1B - Vasopressin V1b receptor - human protein (Function)
 
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AVPR1B »  Vasopressin V1b receptor  (V1bR)
 
Protein also known as:  Antidiuretic hormone receptor 1b.
Gene name:  AVPR1B
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.10.2  
GO molecular function 
Peptide bindingdefinition[GO:0042277]  
1
  • RefGenome
Protein kinase C bindingdefinition[GO:0005080]  
1
  • PINC
Vasopressin receptor activitydefinition[GO:0005000] silver  
1
  • InterPro 2 GO
GO biological process 
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • PINC
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • RefGenome
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • PINC
Positive regulation of vasoconstrictiondefinition[GO:0045907]  
1
  • RefGenome
Regulation of systemic arterial blood pressure by vasopressindefinition[GO:0001992]  
1
  • RefGenome
Response to peptidedefinition[GO:1901652]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+553  
Neuroactive ligand-receptor interaction  hsa04080+553  
Vascular smooth muscle contraction  hsa04270+553  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Vasopressin-like receptors  REACT_17041  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Arginine_vasopressin_receptor_1B
GenomeRNAi: 553
PRO: PR:P47901
Chemistry
GuidetoPHARMACOLOGY: 367