ID4 - DNA-binding protein inhibitor ID-4 - human protein (Function)
 
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ID4 »  DNA-binding protein inhibitor ID-4
 
Protein also known as:  Class B basic helix-loop-helix protein 27 (bHLHb27).
Gene name:  ID4
Entry whose protein(s) existence is based on evidence at protein level
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1 46 1
GENE REF ISO

Function

 show evidences
Overview 
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
RNA polymerase II transcription factor bindingdefinition[GO:0001085] silver  
  • IEAOrtholog Compara
Transcription corepressor activitydefinition[GO:0003714]  
1
  • TASPINC
GO biological process 
Cellular protein localizationdefinition[GO:0034613] silver  
  • IEAOrtholog Compara
Central nervous system myelinationdefinition[GO:0022010] silver  
  • IEAOrtholog Compara
Cerebral cortex neuron differentiationdefinition[GO:0021895] silver  
  • IEAOrtholog Compara
Fat cell differentiationdefinition[GO:0045444] silver  
  • IEAOrtholog Compara
G1/S transition of mitotic cell cycledefinition[GO:0000082] silver  
  • IEAOrtholog Compara
Hippocampus developmentdefinition[GO:0021766] silver  
  • IEAOrtholog Compara
Negative regulation of astrocyte differentiationdefinition[GO:0048712] silver  
  • IEAOrtholog Compara
Negative regulation of fat cell differentiationdefinition[GO:0045599] silver  
  • IEAOrtholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
  • IEAOrtholog Compara
Negative regulation of oligodendrocyte differentiationdefinition[GO:0048715] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAGDB
Neuroblast proliferationdefinition[GO:0007405] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+3400  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ID4
GenomeRNAi: 3400
PRO: PR:P47928