UQCRFS1 - Cytochrome b-c1 complex subunit Rieske, mitochondrial - human protein (Function)
 
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UQCRFS1 »  Cytochrome b-c1 complex subunit Rieske, mitochondrial   [ EC 1.10.2.2 ]
 
Protein also known as:  Ubiquinol-cytochrome c reductase iron-sulfur subunit. Cleaved into:  Cytochrome b-c1 complex subunit 11.
Gene name:  UQCRFS1
Entry whose protein(s) existence is based on evidence at protein level
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1 15 1
GENE REF ISO

Function

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Overview 
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.  
  • CuratedUniProtKB
The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex (By similarity).  
  • CuratedUniProtKB
GO molecular function 
2 iron, 2 sulfur cluster bindingdefinition[GO:0051537]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Ubiquinol-cytochrome-c reductase activitydefinition[GO:0008121]  
  • IEAEC 2 GO
GO biological process 
Response to antibioticdefinition[GO:0046677] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to hormonedefinition[GO:0009725] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.10.2.2: Quinol + 2 ferricytochrome c quinone + 2 ferrocytochrome c + 2 H(+).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 2Fe-2S cluster per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+7386  
Cardiac muscle contraction  hsa04260+7386  
Huntington's disease  hsa05016+7386  
Metabolic pathways  hsa01100+7386  
Oxidative phosphorylation  hsa00190+7386  
Parkinson's disease  hsa05012+7386  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
Note 
The Rieske protein is a high potential 2Fe-2S protein.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Respiratory chain  definition   [KW-0679]
Transport  definition   [KW-0813]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: UQCRFS1
GenomeRNAi: 7386
PRO: PR:P47985