FASLG - Tumor necrosis factor ligand superfamily member 6 - human protein (Function)
 
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FASLG »  Tumor necrosis factor ligand superfamily member 6
 
Protein also known as:  Apoptosis antigen ligand (APTL); CD antigen CD178. Cleaved into:  ADAM10-processed FasL form; FasL intracellular domain; Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form.
Gene name:  FASLG
Family name: Tumor necrosis factor
Entry whose protein(s) existence is based on evidence at protein level
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1 403 2
GENE REF ISO

Function

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Overview 
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.  
1
  • CuratedUniProtKB
The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.  
1
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
Receptor bindingdefinition[GO:0005102]  
1
  • TASPINC
Tumor necrosis factor receptor bindingdefinition[GO:0005164] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
2
  • IGIMGI
  • IMPBHF-UCL
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • IDABHF-UCL
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cellular chloride ion homeostasisdefinition[GO:0030644] silver  
  • IEAOrtholog Compara
Endosomal lumen acidificationdefinition[GO:0048388] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • IDAUniProtKB
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • IDABHF-UCL
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Inflammatory cell apoptotic processdefinition[GO:0006925] silver  
  • IEAOrtholog Compara
Necroptotic processdefinition[GO:0070266]  
1
  • IDABHF-UCL
Necroptotic signaling pathwaydefinition[GO:0097527]  
1
  • IDABHF-UCL
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • IDABHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
2
  • IDAUniProtKB
  • IDAMGI
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell apoptotic processdefinition[GO:2000353]  
1
  • IDABHF-UCL
Positive regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0045742] silver  
  • IEAOrtholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IEPUniProtKB
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Response to growth factordefinition[GO:0070848] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Retinal cell programmed cell deathdefinition[GO:0046666] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
T cell apoptotic processdefinition[GO:0070231]  
1
  • IDAUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+356  
Allograft rejection  hsa05330+356  
Apoptosis  hsa04210+356  
Autoimmune thyroid disease  hsa05320+356  
Chagas disease (American trypanosomiasis)  hsa05142+356  
Cytokine-cytokine receptor interaction  hsa04060+356  
Graft-versus-host disease  hsa05332+356  
Herpes simplex infection  hsa05168+356  
Influenza A  hsa05164+356  
MAPK signaling pathway  hsa04010+356  
Measles  hsa05162+356  
Natural killer cell mediated cytotoxicity  hsa04650+356  
Neurotrophin signaling pathway  hsa04722+356  
Pathways in cancer  hsa05200+356  
Type I diabetes mellitus  hsa04940+356  
According to Reactome, this protein belongs to the following pathway:
FasL/ CD95L signaling  REACT_900  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Cytokine  definition   [KW-0202]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Fas_ligand
GenomeRNAi: 356
PRO: PR:P48023