SLC6A8 - Sodium- and chloride-dependent creatine transporter 1 - human protein (Function)
 
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Protein
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References

 
SLC6A8 »  Sodium- and chloride-dependent creatine transporter 1  (CT1)
 
Protein also known as:  Solute carrier family 6 member 8.
Gene name:  SLC6A8
Entry whose protein(s) existence is based on evidence at protein level
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1 44 4
GENE REF ISO

Function

 show evidences
Overview 
Required for the uptake of creatine in muscles and brain.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter:sodium symporter (nss) family  2.A.22.3.11  
GO molecular function 
Choline transmembrane transporter activitydefinition[GO:0015220] silver  
  • IEAOrtholog Compara
Creatine transmembrane transporter activitydefinition[GO:0005308]  
1
  • NASUniProtKB
Creatine:sodium symporter activitydefinition[GO:0005309] silver  
  • IEAOrtholog Compara
Neurotransmitter:sodium symporter activitydefinition[GO:0005328] silver  
  • IEAInterPro 2 GO
GO biological process 
Amino acid transmembrane transportdefinition[GO:0003333]  
2
  • NASGOC
Cofactor transportdefinition[GO:0051181]  
2
  • NASGOC
Creatine transmembrane transportdefinition[GO:1902598]  
2
  • NASGOC
Creatine transportdefinition[GO:0015881]  
1
  • NASUniProtKB
Ion transmembrane transportdefinition[GO:0034220]  
2
  • NASGOC
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • TASGOC
Transmembrane transportdefinition[GO:0055085]  
2
  • NASGOC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC6A8
GenomeRNAi: 6535
PRO: PR:P48029