SLC6A8 - Sodium- and chloride-dependent creatine transporter 1 - human protein (Function)
 
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Protein
Gene
References

 
SLC6A8 »  Sodium- and chloride-dependent creatine transporter 1  (CT1)
 
Protein also known as:  Solute carrier family 6 member 8.
Gene name:  SLC6A8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for the uptake of creatine in muscles and brain.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter:sodium symporter (nss) family  2.A.22.3.11  
GO molecular function 
Creatine transmembrane transporter activitydefinition[GO:0005308]  
1
  • UniProtKB
Creatine:sodium symporter activitydefinition[GO:0005309] silver  
1
  • InterPro 2 GO
Neurotransmitter:sodium symporter activitydefinition[GO:0005328] silver  
1
  • InterPro 2 GO
GO biological process 
Creatine transmembrane transportdefinition[GO:1902598]  
3
  • GOC
  • InterPro 2 GO
Creatine transportdefinition[GO:0015881]  
1
  • UniProtKB
Muscle contractiondefinition[GO:0006936]  
1
  • PINC
Neurotransmitter transportdefinition[GO:0006836] silver  
1
  • InterPro 2 GO
Sodium ion transportdefinition[GO:0006814]  
1
  • UniProtKB KW
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Creatine metabolism  REACT_813  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC6A8
GenomeRNAi: 6535
PRO: PR:P48029