KCNJ1 - ATP-sensitive inward rectifier potassium channel 1 - human protein (Function)
 
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KCNJ1 »  ATP-sensitive inward rectifier potassium channel 1
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 1.
Gene name:  KCNJ1
Entry whose protein(s) existence is based on evidence at protein level
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1 51 3
GENE REF ISO

Function

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Overview 
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
inward rectifier k(+) channel (irk-c) family  1.A.2.1.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Inward rectifier potassium channel activitydefinition[GO:0005242] silver  
  • IEAInterPro 2 GO
Phosphatidylinositol-4,5-bisphosphate bindingdefinition[GO:0005546]  
1
  • IDABHF-UCL
GO biological process 
Cardiovascular system developmentdefinition[GO:0072358] silver  
  • IEAOrtholog Compara
Excretiondefinition[GO:0007588]  
1
  • TASPINC
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • TASGOC
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Regulation of G-protein activated inward rectifier potassium channel activitydefinition[GO:1900128] silver  
  • IEAOrtholog Compara
Renal sodium ion absorptiondefinition[GO:0070294] silver  
  • IEAOrtholog Compara
Tissue homeostasisdefinition[GO:0001894] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
Inhibited by WNK3.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+3758  
Gastric acid secretion  hsa04971+3758  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ROMK
GenomeRNAi: 3758
PRO: PR:P48048
Chemistry
GuidetoPHARMACOLOGY: 429