KCNJ4 - Inward rectifier potassium channel 4 - human protein (Function)
 
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Protein
Gene
References

 
KCNJ4 »  Inward rectifier potassium channel 4
 
Gene name:  KCNJ4
Entry whose protein(s) existence is based on evidence at protein level
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1 32 1
GENE REF ISO

Function

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Overview 
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Inward rectifier potassium channel activitydefinition[GO:0005242] silver  
  • IEAInterPro 2 GO
PDZ domain bindingdefinition[GO:0030165]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • TASGOC
  • IEAInterPro 2 GO
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cholinergic synapse  hsa04725+3761  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  REACT_75831  
Classical Kir channels  REACT_75870  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  REACT_25004  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNJ4
GenomeRNAi: 3761
PRO: PR:P48050
Chemistry
GuidetoPHARMACOLOGY: 432