KCNJ6 - G protein-activated inward rectifier potassium channel 2 - human protein (Function)
 
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Protein
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References

 
KCNJ6 »  G protein-activated inward rectifier potassium channel 2  (GIRK-2)
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 6.
Gene name:  KCNJ6
Entry whose protein(s) existence is based on evidence at protein level
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1 40 1
GENE REF ISO

Function

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Overview 
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
inward rectifier k(+) channel (irk-c) family  1.A.2.1.10  
GO molecular function 
G-protein activated inward rectifier potassium channel activitydefinition[GO:0015467] silver  
  • IEAInterPro 2 GO
Inward rectifier potassium channel activitydefinition[GO:0005242]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
GO biological process 
Ion transmembrane transportdefinition[GO:0034220]  
2
  • TASGOC
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • TASGOC
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Transmembrane transportdefinition[GO:0055085]  
2
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+3763  
Dopaminergic synapse  hsa04728+3763  
GABAergic synapse  hsa04727+3763  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNJ6
GenomeRNAi: 3763
PRO: PR:P48051
Chemistry
GuidetoPHARMACOLOGY: 435