SLC6A11 - Sodium- and chloride-dependent GABA transporter 3 - human protein (Function)
 
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Protein
Gene
References

 
SLC6A11 »  Sodium- and chloride-dependent GABA transporter 3  (GAT-3)
 
Protein also known as:  Solute carrier family 6 member 11.
Gene name:  SLC6A11
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.  
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  • UniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter:sodium symporter (nss) family  2.A.22.3.9  
GO molecular function 
Gamma-aminobutyric acid:sodium symporter activitydefinition[GO:0005332]  
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  • RefGenome
Neurotransmitter bindingdefinition[GO:0042165] silver  
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  • Ortholog Compara
Neurotransmitter:sodium symporter activitydefinition[GO:0005328] silver  
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  • InterPro 2 GO
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Gamma-aminobutyric acid transportdefinition[GO:0015812]  
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  • RefGenome
Neurotransmitter transportdefinition[GO:0006836]  
1
  • RefGenome
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
GABAergic synapse  hsa04727+6538  
According to Reactome, this protein belongs to the following pathways:
Creatine metabolism  R-HSA-71288  
Na+/Cl- dependent neurotransmitter transporters  R-HSA-442660  
Reuptake of GABA  R-HSA-888593  
 

Keywords

Biological process 
Neurotransmitter transport  definition   [KW-0532]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 6538
PRO: PR:P48066