GABRA4 - Gamma-aminobutyric acid receptor subunit alpha-4 - human protein (Function)
 
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GABRA4 »  Gamma-aminobutyric acid receptor subunit alpha-4
 
Protein also known as:  GABA(A) receptor subunit alpha-4.
Gene name:  GABRA4
Entry whose protein(s) existence is based on evidence at transcript level
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1 31 1
GENE REF ISO

Function

 show evidences
Overview 
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.  
  • CuratedUniProtKB
GO molecular function 
Benzodiazepine receptor activitydefinition[GO:0008503]  
1
  • TASPINC
Chloride channel activitydefinition[GO:0005254]  
  • IEAUniProtKB KW
Extracellular ligand-gated ion channel activitydefinition[GO:0005230] silver  
  • IEAInterPro 2 GO
GABA-A receptor activitydefinition[GO:0004890] silver  
  • IEAInterPro 2 GO
GO biological process 
Central nervous system developmentdefinition[GO:0007417] silver  
  • IEAOrtholog Compara
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
  • IEAInterPro 2 GO
Regulation of response to drugdefinition[GO:2001023] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+2557  
Neuroactive ligand-receptor interaction  hsa04080+2557  
According to Reactome, this protein belongs to the following pathways:
Neuronal System  REACT_13685  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GABRA4
GenomeRNAi: 2557
PRO: PR:P48169
Chemistry
GuidetoPHARMACOLOGY: 407