SOX2 - Transcription factor SOX-2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SOX2 »  Transcription factor SOX-2
 
Gene name:  SOX2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 231 1
GENE REF ISO

Function

 show evidences
Overview 
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
DNA bindingdefinition[GO:0003677]  
5
  • IDAUniProtKB
  • IDAHGNC
miRNA bindingdefinition[GO:0035198]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAMGI
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
3
  • IDAUniProtKB
  • IDAHGNC
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976] silver  
  • IEAOrtholog Compara
GO biological process 
Adenohypophysis developmentdefinition[GO:0021984] silver  
  • IEAOrtholog Compara
Cell cycle arrestdefinition[GO:0007050]  
1
  • IDAUniProtKB
Cerebral cortex developmentdefinition[GO:0021987] silver  
  • IEAOrtholog Compara
Chromatin organizationdefinition[GO:0006325]  
1
  • NASUniProtKB
Detection of mechanical stimulus involved in equilibrioceptiondefinition[GO:0050973] silver  
  • IEAOrtholog Compara
Detection of mechanical stimulus involved in sensory perception of sounddefinition[GO:0050910] silver  
  • IEAOrtholog Compara
Diencephalon morphogenesisdefinition[GO:0048852] silver  
  • IEAOrtholog Compara
Endodermal cell fate specificationdefinition[GO:0001714]  
1
  • IDAMGI
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441] silver  
  • IEAOrtholog Compara
Eye developmentdefinition[GO:0001654]  
1
  • IEPUniProtKB
Forebrain developmentdefinition[GO:0030900]  
1
  • IEPUniProtKB
Forebrain neuron differentiationdefinition[GO:0021879] silver  
  • IEAOrtholog Compara
Glial cell fate commitmentdefinition[GO:0021781]  
1
  • NASUniProtKB
Inner ear developmentdefinition[GO:0048839]  
1
  • IEPUniProtKB
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Lens induction in camera-type eyedefinition[GO:0060235] silver  
  • IEAOrtholog Compara
Lung alveolus developmentdefinition[GO:0048286] silver  
  • IEAOrtholog Compara
Male genitalia developmentdefinition[GO:0030539] silver  
  • IEAOrtholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IDAUniProtKB
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
1
  • IDAUniProtKB
Negative regulation of neuron differentiationdefinition[GO:0045665]  
  • ISSOrtholog Curator
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Neuron fate commitmentdefinition[GO:0048663] silver  
  • IEAOrtholog Compara
Neuronal stem cell maintenancedefinition[GO:0097150]  
  • ISSOrtholog Curator
Olfactory placode formationdefinition[GO:0030910] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
1
  • IDAUniProtKB
Pigment biosynthetic processdefinition[GO:0046148] silver  
  • IEAOrtholog Compara
Pituitary gland developmentdefinition[GO:0021983]  
1
  • IEPUniProtKB
Positive regulation of epithelial cell differentiationdefinition[GO:0030858] silver  
  • IEAOrtholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IDAUniProtKB
Positive regulation of neuroblast proliferationdefinition[GO:0002052] silver  
  • IEAOrtholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Positive regulation of Notch signaling pathwaydefinition[GO:0045747] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDAMGI
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043281]  
1
  • IDAUniProtKB
Regulation of gene expressiondefinition[GO:0010468]  
1
  • IMPUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • IDAHGNC
  • NASUniProtKB
Response to growth factordefinition[GO:0070848]  
1
  • IDAUniProtKB
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611]  
1
  • IEPUniProtKB
Retina morphogenesis in camera-type eyedefinition[GO:0060042] silver  
  • IEAOrtholog Compara
Somatic stem cell maintenancedefinition[GO:0035019]  
3
  • IMPBHF-UCL
  • IDAUniProtKB
Tongue developmentdefinition[GO:0043586] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation  REACT_200759  
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation  REACT_200670  
Transcriptional regulation of pluripotent stem cells  REACT_200812  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SOX2
GenomeRNAi: 6657
PRO: PR:P48431