SOX2 - Transcription factor SOX-2 - human protein (Function)
 
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Gene
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SOX2 »  Transcription factor SOX-2
 
Gene name:  SOX2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 313 1
GENE REF ISO

Function

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Overview 
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).  
2
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
5
  • UniProtKB
  • HGNC
miRNA bindingdefinition[GO:0035198]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • MGI
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
3
  • UniProtKB
  • HGNC
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • UniProtKB
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976] silver  
1
  • Ortholog Compara
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001077] silver  
1
  • Ortholog Compara
GO biological process 
Adenohypophysis developmentdefinition[GO:0021984] silver  
1
  • Ortholog Compara
Cell cycle arrestdefinition[GO:0007050]  
1
  • UniProtKB
Chromatin organizationdefinition[GO:0006325]  
1
  • UniProtKB
Endodermal cell fate specificationdefinition[GO:0001714]  
1
  • MGI
Eye developmentdefinition[GO:0001654]  
1
  • UniProtKB
Forebrain developmentdefinition[GO:0030900]  
1
  • UniProtKB
Glial cell fate commitmentdefinition[GO:0021781]  
1
  • UniProtKB
Inner ear developmentdefinition[GO:0048839]  
1
  • UniProtKB
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • UniProtKB
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
1
  • UniProtKB
Negative regulation of neuron differentiationdefinition[GO:0045665]  
1
  • Ortholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • Ortholog Curator
Neuronal stem cell population maintenancedefinition[GO:0097150]  
1
  • Ortholog Curator
Osteoblast differentiationdefinition[GO:0001649]  
1
  • UniProtKB
Pituitary gland developmentdefinition[GO:0021983]  
1
  • UniProtKB
Positive regulation of cell differentiationdefinition[GO:0045597] silver  
1
  • Ortholog Compara
Positive regulation of cell-cell adhesiondefinition[GO:0022409] silver  
1
  • Ortholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • MGI
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043281]  
1
  • UniProtKB
Regulation of gene expressiondefinition[GO:0010468]  
1
  • UniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • HGNC
  • UniProtKB
Response to growth factordefinition[GO:0070848]  
1
  • UniProtKB
Response to woundingdefinition[GO:0009611]  
1
  • UniProtKB
Somatic stem cell population maintenancedefinition[GO:0035019]  
3
  • BHF-UCL
  • UniProtKB
Tissue regenerationdefinition[GO:0042246] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Deactivation of the beta-catenin transactivating complex  R-HSA-3769402  
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation  R-HSA-2892247  
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation  R-HSA-2892245  
Transcriptional regulation of pluripotent stem cells  R-HSA-452723  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SOX2
GenomeRNAi: 6657
PRO: PR:P48431