SOX9 - Transcription factor SOX-9 - human protein (Function)
 
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SOX9 »  Transcription factor SOX-9
 
Gene name:  SOX9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.  
  • CuratedUniProtKB
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013] silver  
  • IEAOrtholog Compara
bHLH transcription factor bindingdefinition[GO:0043425] silver  
  • IEAOrtholog Compara
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAUniProtKB
Core promoter sequence-specific DNA bindingdefinition[GO:0001046]  
1
  • IDAUniProtKB
Enhancer bindingdefinition[GO:0035326]  
1
  • IDAUniProtKB
Enhancer sequence-specific DNA bindingdefinition[GO:0001158]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein kinase A catalytic subunit bindingdefinition[GO:0034236]  
1
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
  • ISSOrtholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
3
  • IDAUniProtKB
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
2
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDAUniProtKB
GO biological process 
Astrocyte fate commitmentdefinition[GO:0060018] silver  
  • IEAOrtholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IEAOrtholog Compara
cAMP-mediated signalingdefinition[GO:0019933]  
1
  • IDAUniProtKB
Cartilage condensationdefinition[GO:0001502]  
  • ISSOrtholog Curator
Cartilage developmentdefinition[GO:0051216]  
  • ISSOrtholog Curator
Cell fate specificationdefinition[GO:0001708]  
  • ISSOrtholog Curator
Cellular response to epidermal growth factor stimulusdefinition[GO:0071364]  
1
  • ISSUniProtKB
Cellular response to heparindefinition[GO:0071504]  
1
  • ISSUniProtKB
Cellular response to interleukin-1definition[GO:0071347]  
1
  • IEPUniProtKB
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • ISSUniProtKB
Cellular response to retinoic aciddefinition[GO:0071300]  
1
  • IEPUniProtKB
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • IDAUniProtKB
Chondrocyte differentiation involved in endochondral bone morphogenesisdefinition[GO:0003413]  
1
  • IMPUniProtKB
Chondrocyte hypertrophydefinition[GO:0003415]  
  • ISSOrtholog Curator
Chromatin remodelingdefinition[GO:0006338]  
1
  • IDAUniProtKB
Cochlea morphogenesisdefinition[GO:0090103]  
  • ISSOrtholog Curator
Endocardial cushion morphogenesisdefinition[GO:0003203]  
  • ISSOrtholog Curator
Endocrine pancreas developmentdefinition[GO:0031018] silver  
  • IEAOrtholog Compara
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • ISSUniProtKB
Epithelial cell proliferation involved in prostatic bud elongationdefinition[GO:0060517]  
  • ISSOrtholog Curator
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
  • ISSOrtholog Curator
ERK1 and ERK2 cascadedefinition[GO:0070371]  
1
  • ISSUniProtKB
Extracellular matrix organizationdefinition[GO:0030198] silver  
  • IEAOrtholog Compara
Hair follicle developmentdefinition[GO:0001942]  
  • ISSOrtholog Curator
Heart valve developmentdefinition[GO:0003170]  
  • ISSOrtholog Curator
Heart valve formationdefinition[GO:0003188] silver  
  • IEAOrtholog Compara
Heart valve morphogenesisdefinition[GO:0003179]  
  • ISSOrtholog Curator
Intestinal epithelial structure maintenancedefinition[GO:0060729]  
  • ISSOrtholog Curator
Intrahepatic bile duct developmentdefinition[GO:0035622] silver  
  • IEAOrtholog Compara
Limb bud formationdefinition[GO:0060174] silver  
  • IEAOrtholog Compara
Male germ-line sex determinationdefinition[GO:0019100]  
  • ISSOrtholog Curator
Male gonad developmentdefinition[GO:0008584]  
2
  • IEPUniProtKB
Mammary gland developmentdefinition[GO:0030879] silver  
  • IEAOrtholog Compara
Metanephric nephron tubule formationdefinition[GO:0072289]  
  • ISSOrtholog Curator
Morphogenesis of a branching epitheliumdefinition[GO:0061138]  
  • ISSOrtholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Negative regulation of biomineral tissue developmentdefinition[GO:0070168]  
  • ISSOrtholog Curator
Negative regulation of bone mineralizationdefinition[GO:0030502] silver  
  • IEAOrtholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
  • ISSOrtholog Curator
Negative regulation of chondrocyte differentiationdefinition[GO:0032331]  
  • ISSOrtholog Curator
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
  • ISSOrtholog Curator
Negative regulation of immune system processdefinition[GO:0002683]  
  • ISSOrtholog Curator
Negative regulation of myoblast differentiationdefinition[GO:0045662]  
  • ISSOrtholog Curator
Negative regulation of ossificationdefinition[GO:0030279]  
  • ISSOrtholog Curator
Negative regulation of photoreceptor cell differentiationdefinition[GO:0046533]  
  • ISSOrtholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IMPUniProtKB
Neural crest cell developmentdefinition[GO:0014032] silver  
  • IEAOrtholog Compara
Notochord developmentdefinition[GO:0030903] silver  
  • IEAOrtholog Compara
Nucleosome assemblydefinition[GO:0006334]  
1
  • IDAUniProtKB
Oligodendrocyte differentiationdefinition[GO:0048709] silver  
  • IEAOrtholog Compara
Ossificationdefinition[GO:0001503] silver  
  • IEAOrtholog Compara
Otic vesicle formationdefinition[GO:0030916]  
  • ISSOrtholog Curator
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190]  
  • ISSOrtholog Curator
Positive regulation of cartilage developmentdefinition[GO:0061036]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPUniProtKB
Positive regulation of cell proliferation involved in heart morphogenesisdefinition[GO:2000138] silver  
  • IEAOrtholog Compara
Positive regulation of chondrocyte differentiationdefinition[GO:0032332]  
2
  • IDAUniProtKB
Positive regulation of epithelial cell differentiationdefinition[GO:0030858]  
  • ISSOrtholog Curator
Positive regulation of epithelial cell migrationdefinition[GO:0010634]  
1
  • IMPUniProtKB
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • IEPUniProtKB
  • ISSOrtholog Curator
Positive regulation of kidney developmentdefinition[GO:0090184]  
  • ISSOrtholog Curator
Positive regulation of male gonad developmentdefinition[GO:2000020]  
1
  • IDAUniProtKB
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053]  
  • ISSOrtholog Curator
Positive regulation of mesenchymal stem cell differentiationdefinition[GO:2000741]  
1
  • IDAUniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
  • ISSOrtholog Curator
Positive regulation of protein catabolic processdefinition[GO:0045732] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IMPUniProtKB
Prostate gland developmentdefinition[GO:0030850]  
1
  • IEPUniProtKB
Protein complex assemblydefinition[GO:0006461]  
1
  • IDAUniProtKB
Protein kinase B signalingdefinition[GO:0043491] silver  
  • IEAOrtholog Compara
Regulation of apoptotic processdefinition[GO:0042981]  
  • ISSOrtholog Curator
Regulation of cell adhesiondefinition[GO:0030155] silver  
  • IEAOrtholog Compara
Regulation of cell cycle processdefinition[GO:0010564]  
1
  • IMPUniProtKB
Regulation of cell proliferationdefinition[GO:0042127]  
  • ISSOrtholog Curator
Regulation of cell proliferation involved in tissue homeostasisdefinition[GO:0060784]  
  • ISSOrtholog Curator
Renal vesicle inductiondefinition[GO:0072034]  
  • ISSOrtholog Curator
Retina development in camera-type eyedefinition[GO:0060041]  
  • ISSOrtholog Curator
Retinal rod cell differentiationdefinition[GO:0060221]  
  • ISSOrtholog Curator
Sertoli cell developmentdefinition[GO:0060009] silver  
  • IEAOrtholog Compara
Sertoli cell differentiationdefinition[GO:0060008]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
  • ISSOrtholog Curator
Skeletal system developmentdefinition[GO:0001501]  
1
  • IMPUniProtKB
Somatic stem cell maintenancedefinition[GO:0035019]  
  • ISSOrtholog Curator
Spermatogenesisdefinition[GO:0007283]  
  • ISSOrtholog Curator
Tissue homeostasisdefinition[GO:0001894]  
  • ISSOrtholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
2
  • IDAGOC
Ureter morphogenesisdefinition[GO:0072197] silver  
  • IEAOrtholog Compara
Ureter urothelium developmentdefinition[GO:0072190] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SOX9
GenomeRNAi: 6662
PRO: PR:P48436