ARCN1 - Coatomer subunit delta - human protein (Function)
 
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ARCN1 »  Coatomer subunit delta
 
Protein also known as:  Delta-coat protein (Delta-COP).
Gene name:  ARCN1
Entry whose protein(s) existence is based on evidence at protein level
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1 23 2
GENE REF ISO

Function

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Overview 
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).  
  • CuratedUniProtKB
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
  • IEAOrtholog Compara
Cerebellar Purkinje cell layer maturationdefinition[GO:0021691] silver  
  • IEAOrtholog Compara
Intracellular protein transportdefinition[GO:0006886] silver  
  • IEAInterPro 2 GO
Pigmentationdefinition[GO:0043473] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Membrane Trafficking  REACT_11123  
 

Keywords

Biological process 
ER-Golgi transport  definition   [KW-0931]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 372
PRO: PR:P48444