LSS - Lanosterol synthase - human protein (Function)
 
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LSS »  Lanosterol synthase   [ EC 5.4.99.7 ]
 
Protein also known as:  2,3-epoxysqualene--lanosterol cyclase.
Gene name:  LSS
Family name: Terpene cyclase/mutase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.  
1
  • CuratedUniProtKB
GO molecular function 
Lanosterol synthase activitydefinition[GO:0000250]  
  • IEAEC 2 GO
GO biological process 
Cholesterol biosynthetic processdefinition[GO:0006695]  
1
  • IMPBHF-UCL
Steroid metabolic processdefinition[GO:0008202]  
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  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.4.99.7: (3S)-2,3-epoxy-2,3-dihydrosqualene lanosterol.  
2
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+4047  
Steroid biosynthesis  hsa00100+4047  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Steroid biosynthesis  definition   [KW-0752]
Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Lanosterol_synthase
GenomeRNAi: 4047
PRO: PR:P48449
Chemistry
GuidetoPHARMACOLOGY: 2434