KCNJ5 - G protein-activated inward rectifier potassium channel 4 - human protein (Function)
 
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Protein
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KCNJ5 »  G protein-activated inward rectifier potassium channel 4  (GIRK-4)
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 5.
Gene name:  KCNJ5
Entry whose protein(s) existence is based on evidence at protein level
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1 61 1
GENE REF ISO

Function

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Overview 
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
inward rectifier k(+) channel (irk-c) family  1.A.2.1.3  
GO molecular function 
G-protein activated inward rectifier potassium channel activitydefinition[GO:0015467]  
1
  • TASUniProtKB
Contributes to inward rectifier potassium channel activitydefinition[GO:0005242]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • IDAGOC
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Dopaminergic synapse  hsa04728+3762  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNJ5
GenomeRNAi: 3762
PRO: PR:P48544
Chemistry
GuidetoPHARMACOLOGY: 437