GIPR - Gastric inhibitory polypeptide receptor - human protein (Function)
 
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GIPR »  Gastric inhibitory polypeptide receptor  (GIP-R)
 
Protein also known as:  Glucose-dependent insulinotropic polypeptide receptor.
Gene name:  GIPR
Entry whose protein(s) existence is based on evidence at protein level
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1 39 3
GENE REF ISO

Function

 show evidences
Overview 
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.4.5  
GO molecular function 
Gastric inhibitory peptide receptor activitydefinition[GO:0016519] silver  
  • IEAOrtholog Compara
Peptide hormone bindingdefinition[GO:0017046] silver  
  • IEAOrtholog Compara
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Desensitization of G-protein coupled receptor protein signaling pathwaydefinition[GO:0002029] silver  
  • IEAOrtholog Compara
Endocrine pancreas developmentdefinition[GO:0031018] silver  
  • IEAOrtholog Compara
Gastric inhibitory peptide signaling pathwaydefinition[GO:0038192] silver  
  • IEAOrtholog Compara
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Positive regulation of insulin secretiondefinition[GO:0032024] silver  
  • IEAOrtholog Compara
Response to axon injurydefinition[GO:0048678] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Response to fatty aciddefinition[GO:0070542] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2696  
According to Reactome, this protein belongs to the following pathways:
G alpha (s) signalling events  REACT_19327  
Glucagon-type ligand receptors  REACT_18377  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Gastric_inhibitory_polypeptide_receptor
GenomeRNAi: 2696
PRO: PR:P48546
Chemistry
GuidetoPHARMACOLOGY: 248