KCNC1 - Potassium voltage-gated channel subfamily C member 1 - human protein (Function)
 
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KCNC1 »  Potassium voltage-gated channel subfamily C member 1
 
Protein also known as:  Voltage-gated potassium channel subunit Kv3.1.
Gene name:  KCNC1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 2
GENE REF ISO

Function

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Overview 
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.  
2
  • UniProtKB
GO molecular function 
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
2
  • RefGenome
  • Ortholog Curator
Ion channel bindingdefinition[GO:0044325] silver  
1
  • Ortholog Compara
Kinesin bindingdefinition[GO:0019894] silver  
1
  • Ortholog Compara
Voltage-gated potassium channel activitydefinition[GO:0005249]  
1
  • PINC
GO biological process 
Cellular response to drugdefinition[GO:0035690] silver  
1
  • Ortholog Compara
Cerebellum developmentdefinition[GO:0021549] silver  
1
  • Ortholog Compara
Globus pallidus developmentdefinition[GO:0021759] silver  
1
  • Ortholog Compara
Positive regulation of potassium ion transmembrane transportdefinition[GO:1901381] silver  
1
  • Ortholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • RefGenome
  • Ortholog Curator
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • InterPro 2 GO
Protein tetramerizationdefinition[GO:0051262]  
1
  • UniProtKB
Response to aminedefinition[GO:0014075] silver  
1
  • Ortholog Compara
Response to auditory stimulusdefinition[GO:0010996] silver  
1
  • Ortholog Compara
Response to fibroblast growth factordefinition[GO:0071774] silver  
1
  • Ortholog Compara
Response to light intensitydefinition[GO:0009642] silver  
1
  • Ortholog Compara
Response to nerve growth factordefinition[GO:1990089] silver  
1
  • Ortholog Compara
Response to potassium iondefinition[GO:0035864] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Voltage gated Potassium channels  R-HSA-1296072  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 3746
PRO: PR:P48547