KCNJ3 - G protein-activated inward rectifier potassium channel 1 - human protein (Function)
 
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KCNJ3 »  G protein-activated inward rectifier potassium channel 1  (GIRK-1)
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 3.
Gene name:  KCNJ3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 2
GENE REF ISO

Function

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Overview 
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
inward rectifier k(+) channel (irk-c) family  1.A.2.1.12  
GO molecular function 
G-protein activated inward rectifier potassium channel activitydefinition[GO:0015467] silver  
  • IEAInterPro 2 GO
Contributes to inward rectifier potassium channel activitydefinition[GO:0005242]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • IDAGOC
  • IEAInterPro 2 GO
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Response to electrical stimulusdefinition[GO:0051602] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+3760  
Dopaminergic synapse  hsa04728+3760  
Glutamatergic synapse  hsa04724+3760  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  REACT_75831  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  REACT_25004  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNJ3
GenomeRNAi: 3760
PRO: PR:P48549
Chemistry
GuidetoPHARMACOLOGY: 434