IFNAR2 - Interferon alpha/beta receptor 2 - human protein (Function)
 
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IFNAR2 »  Interferon alpha/beta receptor 2  (IFN-R-2)
 
Protein also known as:  Interferon alpha binding protein.
Gene name:  IFNAR2
Entry whose protein(s) existence is based on evidence at protein level
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1 64 3
GENE REF ISO

Function

 show evidences
Overview 
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation.  
5
  • CuratedUniProtKB
Isoform  Iso 3   Is a potent inhibitor of type I IFN receptor activity.  
5
  • CuratedUniProtKB
Isoforms  Iso 1 and Iso 2   Are directly involved in signal transduction due to their association with the TYR kinase, JAK1.  
5
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Isoform  Iso 3   Type I interferon bindingdefinition[GO:0019962]  
1
  • IPIUniProtKB
Type I interferon receptor activitydefinition[GO:0004905]  
1
  • IDAUniProtKB
GO biological process 
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
JAK-STAT cascadedefinition[GO:0007259]  
1
  • TASPINC
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357] silver  
  • IEAOrtholog Compara
Response to interferon-alphadefinition[GO:0035455]  
1
  • IDAUniProtKB
Response to virusdefinition[GO:0009615]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+3455  
Hepatitis C  hsa05160+3455  
Herpes simplex infection  hsa05168+3455  
Influenza A  hsa05164+3455  
Jak-STAT signaling pathway  hsa04630+3455  
Measles  hsa05162+3455  
Natural killer cell mediated cytotoxicity  hsa04650+3455  
Osteoclast differentiation  hsa04380+3455  
Toll-like receptor signaling pathway  hsa04620+3455  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IFNAR2
GenomeRNAi: 3455
PRO: PR:P48551