GSS - Glutathione synthetase - human protein (Function)
 
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Gene
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GSS »  Glutathione synthetase   [ EC 6.3.2.3 ]  (GSH-S)
 
Protein also known as:  Glutathione synthase.
Gene name:  GSS
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Glutathione bindingdefinition[GO:0043295]  
1
  • UniProtKB
Glycine bindingdefinition[GO:0016594] silver  
1
  • Ortholog Compara
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Cellular amino acid metabolic processdefinition[GO:0006520]  
1
  • PINC
Glutathione biosynthetic processdefinition[GO:0006750]  
1
  • UniPathway
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Response to amino aciddefinition[GO:0043200] silver  
1
  • Ortholog Compara
Response to cadmium iondefinition[GO:0046686] silver  
1
  • Ortholog Compara
Response to nutrient levelsdefinition[GO:0031667] silver  
1
  • Ortholog Compara
Response to oxidative stressdefinition[GO:0006979]  
1
  • PINC
Response to tumor necrosis factordefinition[GO:0034612] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.2.3: ATP + gamma-L-glutamyl-L-cysteine + glycine ADP + phosphate + glutathione.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 1 Mg(2+) ion per subunit.  
2
  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Glutathione metabolism  hsa00480+2937  
Metabolic pathways  hsa01100+2937  
According to Reactome, this protein belongs to the following pathways:
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)  REACT_267887  
Glutathione synthesis and recycling  REACT_6960  
 
More information is available from:
 

Keywords

Biological process 
Glutathione biosynthesis  definition   [KW-0317]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P48637
Other
GenomeRNAi: 2937
PRO: PR:P48637