SLC1A6 - Excitatory amino acid transporter 4 - human protein (Function)
 
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Protein
Gene
References

 
SLC1A6 »  Excitatory amino acid transporter 4
 
Protein also known as:  Sodium-dependent glutamate/aspartate transporter.
Gene name:  SLC1A6
Entry whose protein(s) existence is based on evidence at protein level
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1 26 2
GENE REF ISO

Function

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Overview 
Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family  2.A.23.2.8  
GO molecular function 
L-aspartate transmembrane transporter activitydefinition[GO:0015183]  
1
  • PINC
L-glutamate transmembrane transporter activitydefinition[GO:0005313] silver  
1
  • Ortholog Compara
Sodium:dicarboxylate symporter activitydefinition[GO:0017153] silver  
1
  • InterPro 2 GO
GO biological process 
Aspartate transportdefinition[GO:0015810]  
1
  • PINC
L-aspartate transmembrane transportdefinition[GO:0089712]  
1
  • GOC
L-glutamate transmembrane transportdefinition[GO:0089711]  
1
  • Ortholog Compara
L-glutamate transportdefinition[GO:0015813]  
1
  • PINC
Regulation of membrane potentialdefinition[GO:0042391] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Glutamatergic synapse  hsa04724+6511  
According to Reactome, this protein belongs to the following pathways:
Glutamate Neurotransmitter Release Cycle  REACT_12591  
Transport of inorganic cations/anions and amino acids/oligopeptides  REACT_19397  
 

Keywords

Biological process 
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Excitatory_amino-acid_transporter_4
GenomeRNAi: 6511
PRO: PR:P48664
Chemistry
GuidetoPHARMACOLOGY: 871