NES - Nestin - human protein (Function)
 
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Protein
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NES »  Nestin
 
Gene name:  NES
Family name: Intermediate filament
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Intermediate filament bindingdefinition[GO:0019215]  
  • ISSOrtholog Curator
Structural molecule activitydefinition[GO:0005198] silver  
  • IEAInterPro 2 GO
GO biological process 
Brain developmentdefinition[GO:0007420]  
  • ISSOrtholog Curator
Cell projection morphogenesisdefinition[GO:0048858] silver  
  • IEAOrtholog Compara
Central nervous system developmentdefinition[GO:0007417]  
1
  • NASUniProtKB
Embryonic camera-type eye developmentdefinition[GO:0031076]  
  • ISSOrtholog Curator
G2/M transition of mitotic cell cycledefinition[GO:0000086]  
1
  • IDADFLAT
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • IDAUniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of protein bindingdefinition[GO:0032091]  
1
  • IDAUniProtKB
Positive regulation of intermediate filament depolymerizationdefinition[GO:0030844]  
  • ISSOrtholog Curator
Positive regulation of neural precursor cell proliferationdefinition[GO:2000179]  
  • ISSOrtholog Curator
Stem cell proliferationdefinition[GO:0072089]  
1
  • IMPDFLAT
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Nestin_(protein)
GenomeRNAi: 10763
PRO: PR:P48681