CSNK1A1 - Casein kinase I isoform alpha - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CSNK1A1 »  Casein kinase I isoform alpha   [ EC 2.7.11.1 ]  (CKI-alpha)
 
Protein also known as:  CK1.
Gene name:  CSNK1A1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 63 2
GENE REF ISO

Function

 show evidences
Overview 
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • TASUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Cell morphogenesisdefinition[GO:0000902] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Mitosisdefinition[GO:0007067]  
  • IEAUniProtKB KW
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Hedgehog signaling pathway  hsa04340+1452  
Wnt signaling pathway  hsa04310+1452  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Casein_kinase_1,_alpha_1
GenomeRNAi: 1452
PRO: PR:P48729
Chemistry
GuidetoPHARMACOLOGY: 1995