IDH2 - Isocitrate dehydrogenase [NADP], mitochondrial - human protein (Function)
 
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IDH2 »  Isocitrate dehydrogenase [NADP], mitochondrial   [ EC 1.1.1.42 ]  (IDH)
 
Protein also known as:  Oxalosuccinate decarboxylase.
Gene name:  IDH2
Entry whose protein(s) existence is based on evidence at protein level
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1 162 1
GENE REF ISO

Function

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Overview 
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.  
  • CuratedUniProtKB
GO molecular function 
Isocitrate dehydrogenase (NADP+) activitydefinition[GO:0004450]  
  • ISSOrtholog Curator
Magnesium ion bindingdefinition[GO:0000287]  
  • ISSOrtholog Curator
NAD bindingdefinition[GO:0051287] silver  
  • IEAInterPro 2 GO
GO biological process 
2-oxoglutarate metabolic processdefinition[GO:0006103]  
  • ISSOrtholog Curator
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • NASPINC
Glyoxylate cycledefinition[GO:0006097]  
  • IEAUniProtKB KW
Isocitrate metabolic processdefinition[GO:0006102]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.42: Isocitrate + NADP(+) 2-oxoglutarate + CO(2) + NADPH.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium or manganese ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+3418  
Glutathione metabolism  hsa00480+3418  
Metabolic pathways  hsa01100+3418  
Peroxisome  hsa04146+3418  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Glyoxylate bypass  definition   [KW-0329]
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IDH2
GenomeRNAi: 3418
PRO: PR:P48735