TRPC1 - Short transient receptor potential channel 1 - human protein (Function)
 
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TRPC1 »  Short transient receptor potential channel 1  (TrpC1)
 
Protein also known as:  Transient receptor protein 1 (TRP-1).
Gene name:  TRPC1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 115 2
GENE REF ISO

Function

 show evidences
Overview 
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.1.3  
GO molecular function 
Calcium channel activitydefinition[GO:0005262]  
1
  • TASPINC
Inositol 1,4,5 trisphosphate bindingdefinition[GO:0070679]  
1
  • IDABHF-UCL
Isoform  Long   Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIBHF-UCL
Store-operated calcium channel activitydefinition[GO:0015279] silver  
  • IEAOrtholog Compara
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
1
  • TASPINC
Cytosolic calcium ion homeostasisdefinition[GO:0051480]  
1
  • IDABHF-UCL
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281]  
1
  • IDABHF-UCL
Response to calcium iondefinition[GO:0051592]  
2
  • IDABHF-UCL
Saliva secretiondefinition[GO:0046541] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+7220  
Glutamatergic synapse  hsa04724+7220  
Pancreatic secretion  hsa04972+7220  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Immune System  REACT_6900  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPC1
GenomeRNAi: 7220
PRO: PR:P48995
Chemistry
GuidetoPHARMACOLOGY: 486