ALDH9A1 - 4-trimethylaminobutyraldehyde dehydrogenase - human protein (Function)
 
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Protein
Gene
References

 
ALDH9A1 »  4-trimethylaminobutyraldehyde dehydrogenase   [ EC 1.2.1.47 ]  (TMABADH)
 
Protein also known as:  Aldehyde dehydrogenase family 9 member A1 [EC 1.2.1.3].
Gene name:  ALDH9A1
Family name: Aldehyde dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.  
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  • CuratedUniProtKB
GO molecular function 
1-pyrroline dehydrogenase activitydefinition[GO:0033737]  
  • IEAEC 2 GO
4-trimethylammoniobutyraldehyde dehydrogenase activitydefinition[GO:0047105]  
  • IEAEC 2 GO
Aldehyde dehydrogenase (NAD) activitydefinition[GO:0004029]  
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  • IDAUniProtKB
Amine bindingdefinition[GO:0043176] silver  
  • IEAOrtholog Compara
Aminobutyraldehyde dehydrogenase activitydefinition[GO:0019145]  
2
  • IDAUniProtKB
NAD bindingdefinition[GO:0051287] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Carnitine biosynthetic processdefinition[GO:0045329]  
  • IEAUniPathway
Cellular aldehyde metabolic processdefinition[GO:0006081]  
1
  • IDAUniProtKB
Hormone metabolic processdefinition[GO:0042445]  
1
  • TASUniProtKB
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Neurotransmitter biosynthetic processdefinition[GO:0042136]  
1
  • IDAUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.2.1.47: 4-trimethylammoniobutanal + NAD(+) + H(2)O 4-trimethylammoniobutanoate + NADH.  
  • CuratedUniProtKB
EC 1.2.1.3: An aldehyde + NAD(+) + H(2)O a carboxylate + NADH.  
  • CuratedUniProtKB
EC 1.2.1.19: 4-aminobutanal + NAD(+) + H(2)O 4-aminobutanoate + NADH.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+223  
Ascorbate and aldarate metabolism  hsa00053+223  
beta-Alanine metabolism  hsa00410+223  
Fatty acid metabolism  hsa00071+223  
Glycerolipid metabolism  hsa00561+223  
Glycolysis / Gluconeogenesis  hsa00010+223  
Histidine metabolism  hsa00340+223  
Lysine degradation  hsa00310+223  
Metabolic pathways  hsa01100+223  
Propanoate metabolism  hsa00640+223  
Pyruvate metabolism  hsa00620+223  
Tryptophan metabolism  hsa00380+223  
Valine, leucine and isoleucine degradation  hsa00280+223  
According to Reactome, this protein belongs to the following pathway:
Carnitine synthesis  REACT_2125  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 11 uM for 4-aminobutyraldehyde
Dependence
pH Optimum pH is about 9.4 with propionaldehyde as substrate, and 7.5 with 4-aminobutyraldehyde as substrate.

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P49189
Other
GeneWiki: Aldehyde_dehydrogenase_9_family,_member_A1
GenomeRNAi: 223
PRO: PR:P49189