CX3CR1 - CX3C chemokine receptor 1 - human protein (Function)
 
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CX3CR1 »  CX3C chemokine receptor 1  (CX3CR1)
 
Protein also known as:  Beta chemokine receptor-like 1.
Gene name:  CX3CR1
Entry whose protein(s) existence is based on evidence at protein level
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1 153 4
GENE REF ISO

Function

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Overview 
Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro).  
  • CuratedUniProtKB
Isoforms  Iso 2 and Iso 3   Seem to be more potent HIV-1 coreceptors than isoform 1.  
  • CuratedUniProtKB
GO molecular function 
C-X3-C chemokine receptor activitydefinition[GO:0016495] silver  
  • IEAOrtholog Compara
Chemokine receptor activitydefinition[GO:0004950]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155] silver  
  • IEAInterPro 2 GO
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560] silver  
  • IEAOrtholog Compara
Cerebral cortex cell migrationdefinition[GO:0021795] silver  
  • IEAOrtholog Compara
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • TASGOC
  • IEAInterPro 2 GO
  • IEAOrtholog Compara
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Macrophage chemotaxisdefinition[GO:0048246] silver  
  • IEAOrtholog Compara
Microglial cell activation involved in immune responsedefinition[GO:0002282] silver  
  • IEAOrtholog Compara
Negative regulation of angiogenesisdefinition[GO:0016525] silver  
  • IEAOrtholog Compara
Negative regulation of cell migrationdefinition[GO:0030336] silver  
  • IEAOrtholog Compara
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611]  
1
  • TASPINC
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+1524  
Cytokine-cytokine receptor interaction  hsa04060+1524  
According to Reactome, this protein belongs to the following pathway:
Chemokine receptors bind chemokines  REACT_15344  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CX3CR1
GenomeRNAi: 1524
PRO: PR:P49238
Chemistry
GuidetoPHARMACOLOGY: 74