SLC11A1 - Natural resistance-associated macrophage protein 1 - human protein (Function)
 
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SLC11A1 »  Natural resistance-associated macrophage protein 1  (NRAMP 1)
 
Protein also known as:  Solute carrier family 11 member 1.
Gene name:  SLC11A1
Family name: NRAMP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 2
GENE REF ISO

Function

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Overview 
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the metal ion (mn(2+)-iron) transporter (nramp) family  2.A.55.2.3  
GO molecular function 
Manganese ion transmembrane transporter activitydefinition[GO:0005384]  
1
  • Ortholog Curator
Metal ion:proton antiporter activitydefinition[GO:0051139]  
1
  • BHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Transition metal ion transmembrane transporter activitydefinition[GO:0046915]  
1
  • BHF-UCL
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147]  
1
  • Ortholog Curator
Antigen processing and presentation of peptide antigendefinition[GO:0048002]  
1
  • Ortholog Curator
Cadmium ion transmembrane transportdefinition[GO:0070574]  
1
  • BHF-UCL
Cellular cadmium ion homeostasisdefinition[GO:0006876]  
1
  • BHF-UCL
Cellular iron ion homeostasisdefinition[GO:0006879]  
1
  • BHF-UCL
Defense response to bacteriumdefinition[GO:0042742]  
1
  • Ortholog Curator
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
1
  • Ortholog Curator
Defense response to protozoandefinition[GO:0042832]  
1
  • Ortholog Curator
Divalent metal ion exportdefinition[GO:0070839]  
1
  • BHF-UCL
Inflammatory responsedefinition[GO:0006954]  
1
  • Ortholog Curator
Interleukin-2 productiondefinition[GO:0032623]  
1
  • Ortholog Curator
Interleukin-3 productiondefinition[GO:0032632]  
1
  • Ortholog Curator
Iron ion homeostasisdefinition[GO:0055072]  
1
  • Ortholog Curator
Iron ion transportdefinition[GO:0006826]  
1
  • BHF-UCL
L-arginine importdefinition[GO:0043091]  
1
  • Ortholog Curator
Macrophage activationdefinition[GO:0042116]  
1
  • Ortholog Curator
Manganese ion transmembrane transportdefinition[GO:0071421] silver  
1
  • Ortholog Compara
Manganese ion transportdefinition[GO:0006828]  
1
  • Ortholog Curator
MHC class II biosynthetic processdefinition[GO:0045342]  
1
  • Ortholog Curator
mRNA stabilizationdefinition[GO:0048255]  
1
  • Ortholog Curator
Multicellular organismal iron ion homeostasisdefinition[GO:0060586]  
1
  • Ortholog Curator
Negative regulation of cytokine productiondefinition[GO:0001818]  
1
  • Ortholog Curator
Nitrite transportdefinition[GO:0015707]  
1
  • Ortholog Curator
Phagocytosisdefinition[GO:0006909]  
1
  • Ortholog Curator
Positive regulation of cytokine productiondefinition[GO:0001819]  
1
  • Ortholog Curator
Positive regulation of dendritic cell antigen processing and presentationdefinition[GO:0002606]  
1
  • Ortholog Curator
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • Ortholog Curator
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
1
  • Ortholog Curator
Positive regulation of phagocytosisdefinition[GO:0050766]  
1
  • Ortholog Curator
Positive regulation of T-helper 1 type immune responsedefinition[GO:0002827]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • Ortholog Curator
Protein import into nucleus, translocationdefinition[GO:0000060] silver  
1
  • Ortholog Compara
Respiratory burstdefinition[GO:0045730]  
1
  • Ortholog Curator
Response to bacteriumdefinition[GO:0009617]  
1
  • UniProtKB
Response to interferon-gammadefinition[GO:0034341]  
1
  • Ortholog Curator
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • Ortholog Curator
T cell cytokine productiondefinition[GO:0002369]  
1
  • Ortholog Curator
T cell proliferation involved in immune responsedefinition[GO:0002309]  
1
  • Ortholog Curator
Vacuolar acidificationdefinition[GO:0007035]  
1
  • Ortholog Curator
Wound healingdefinition[GO:0042060]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+6556  
Mineral absorption  hsa04978+6556  
According to Reactome, this protein belongs to the following pathways:
Metal ion SLC transporters  REACT_20547  
Phagosomal maturation (early endosomal stage)  REACT_121256  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Iron transport  definition   [KW-0410]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC11A1
GenomeRNAi: 6556
PRO: PR:P49279