SLC11A1 - Natural resistance-associated macrophage protein 1 - human protein (Function)
 
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SLC11A1 »  Natural resistance-associated macrophage protein 1  (NRAMP 1)
 
Protein also known as:  Solute carrier family 11 member 1.
Gene name:  SLC11A1
Family name: NRAMP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 2
GENE REF ISO

Function

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Overview 
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the metal ion (mn(2+)-iron) transporter (nramp) family  2.A.55.2.3  
GO molecular function 
Manganese ion transmembrane transporter activitydefinition[GO:0005384]  
  • ISSOrtholog Curator
Metal ion:proton antiporter activitydefinition[GO:0051139]  
1
  • IGIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Transition metal ion transmembrane transporter activitydefinition[GO:0046915]  
1
  • IGIBHF-UCL
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147]  
  • ISSOrtholog Curator
Antigen processing and presentation of peptide antigendefinition[GO:0048002]  
  • ISSOrtholog Curator
Cadmium ion transmembrane transportdefinition[GO:0070574]  
1
  • IGIBHF-UCL
Cellular cadmium ion homeostasisdefinition[GO:0006876]  
1
  • IGIBHF-UCL
Cellular iron ion homeostasisdefinition[GO:0006879]  
1
  • IMPBHF-UCL
Defense response to bacteriumdefinition[GO:0042742]  
  • ISSOrtholog Curator
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
  • ISSOrtholog Curator
Defense response to protozoandefinition[GO:0042832]  
  • ISSOrtholog Curator
Divalent metal ion exportdefinition[GO:0070839]  
1
  • ISSBHF-UCL
Inflammatory responsedefinition[GO:0006954]  
  • ISSOrtholog Curator
Interleukin-2 productiondefinition[GO:0032623]  
  • ISSOrtholog Curator
Interleukin-3 productiondefinition[GO:0032632]  
  • ISSOrtholog Curator
Iron ion homeostasisdefinition[GO:0055072]  
  • ISSOrtholog Curator
Iron ion transportdefinition[GO:0006826]  
1
  • IMPBHF-UCL
L-arginine importdefinition[GO:0043091]  
  • ISSOrtholog Curator
Macrophage activationdefinition[GO:0042116]  
  • ISSOrtholog Curator
Manganese ion transmembrane transportdefinition[GO:0071421] silver  
  • IEAOrtholog Compara
Manganese ion transportdefinition[GO:0006828]  
  • ISSOrtholog Curator
MHC class II biosynthetic processdefinition[GO:0045342]  
  • ISSOrtholog Curator
mRNA stabilizationdefinition[GO:0048255]  
  • ISSOrtholog Curator
Multicellular organismal iron ion homeostasisdefinition[GO:0060586]  
  • ISSOrtholog Curator
Negative regulation of cytokine productiondefinition[GO:0001818]  
  • ISSOrtholog Curator
Nitrite transportdefinition[GO:0015707]  
  • ISSOrtholog Curator
Phagocytosisdefinition[GO:0006909]  
  • ISSOrtholog Curator
Positive regulation of cytokine productiondefinition[GO:0001819]  
  • ISSOrtholog Curator
Positive regulation of dendritic cell antigen processing and presentationdefinition[GO:0002606]  
  • ISSOrtholog Curator
Positive regulation of gene expressiondefinition[GO:0010628]  
  • ISSOrtholog Curator
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
  • ISSOrtholog Curator
Positive regulation of phagocytosisdefinition[GO:0050766]  
  • ISSOrtholog Curator
Positive regulation of T-helper 1 type immune responsedefinition[GO:0002827]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Protein import into nucleus, translocationdefinition[GO:0000060] silver  
  • IEAOrtholog Compara
Respiratory burstdefinition[GO:0045730]  
  • ISSOrtholog Curator
Response to bacteriumdefinition[GO:0009617]  
1
  • IDAUniProtKB
Response to interferon-gammadefinition[GO:0034341]  
  • ISSOrtholog Curator
Response to lipopolysaccharidedefinition[GO:0032496]  
  • ISSOrtholog Curator
T cell cytokine productiondefinition[GO:0002369]  
  • ISSOrtholog Curator
T cell proliferation involved in immune responsedefinition[GO:0002309]  
  • ISSOrtholog Curator
Vacuolar acidificationdefinition[GO:0007035]  
  • ISSOrtholog Curator
Wound healingdefinition[GO:0042060]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+6556  
Mineral absorption  hsa04978+6556  
According to Reactome, this protein belongs to the following pathways:
Metal ion SLC transporters  REACT_20547  
Phagosomal maturation (early endosomal stage)  REACT_121256  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Iron transport  definition   [KW-0410]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC11A1
GenomeRNAi: 6556
PRO: PR:P49279