SLC11A2 - Natural resistance-associated macrophage protein 2 - human protein (Function)
 
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SLC11A2 »  Natural resistance-associated macrophage protein 2  (NRAMP 2)
 
Protein also known as:  Solute carrier family 11 member 2.
Gene name:  SLC11A2
Family name: NRAMP
Entry whose protein(s) existence is based on evidence at protein level
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1 80 5
GENE REF ISO

Function

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Overview 
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.  
5
  • UniProtKB
According to TCDB this is a transporter from family:
the metal ion (mn(2+)-iron) transporter (nramp) family  2.A.55.2.1  
GO molecular function 
Cadmium ion bindingdefinition[GO:0046870]  
1
  • UniProtKB
Cadmium ion transmembrane transporter activitydefinition[GO:0015086]  
2
  • UniProtKB
  • BHF-UCL
Not Isoform  Iso 3   Calcium ion transmembrane transporter activitydefinition[GO:0015085]  
1
  • UniProtKB
Not Isoform  Iso 3   Chromium ion transmembrane transporter activitydefinition[GO:0070835]  
1
  • UniProtKB
Cobalt ion bindingdefinition[GO:0050897] silver  
1
  • Ortholog Compara
Cobalt ion transmembrane transporter activitydefinition[GO:0015087]  
2
  • UniProtKB
  • Ortholog Compara
Copper ion bindingdefinition[GO:0005507] silver  
1
  • Ortholog Compara
Copper ion transmembrane transporter activitydefinition[GO:0005375]  
1
  • BHF-UCL
Ferrous iron transmembrane transporter activitydefinition[GO:0015093]  
3
  • UniProtKB
  • BHF-UCL
Ferrous iron uptake transmembrane transporter activitydefinition[GO:0015639]  
1
  • UniProtKB
Hydrogen ion transmembrane transporter activitydefinition[GO:0015078] silver  
1
  • Ortholog Compara
Isoforms  Iso 2 and Iso 1   Inorganic cation transmembrane transporter activitydefinition[GO:0022890]  
1
  • UniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
1
  • Ortholog Compara
Lead ion transmembrane transporter activitydefinition[GO:0015094]  
2
  • UniProtKB
  • BHF-UCL
Manganese ion bindingdefinition[GO:0030145] silver  
1
  • Ortholog Compara
Manganese ion transmembrane transporter activitydefinition[GO:0005384]  
2
  • UniProtKB
  • BHF-UCL
Nickel cation bindingdefinition[GO:0016151] silver  
1
  • Ortholog Compara
Nickel cation transmembrane transporter activitydefinition[GO:0015099]  
2
  • UniProtKB
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
Solute:proton symporter activitydefinition[GO:0015295]  
1
  • UniProtKB
Transition metal ion transmembrane transporter activitydefinition[GO:0046915]  
1
  • UniProtKB
Isoforms  Iso 1 and Iso 3   Vanadium ion transmembrane transporter activitydefinition[GO:0015100]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • Ortholog Compara
Isoform  Iso 1 but not isoform  Iso 3   Zinc ion transmembrane transporter activitydefinition[GO:0005385]  
1
  • UniProtKB
GO biological process 
Isoform  Iso 1   Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • UniProtKB
Cadmium ion transmembrane transportdefinition[GO:0070574]  
3
  • UniProtKB
  • BHF-UCL
Isoform  Iso 2   Cation transmembrane transportdefinition[GO:0098655]  
1
  • GOC
Cellular copper ion homeostasisdefinition[GO:0006878] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
Cellular response to iron iondefinition[GO:0071281] silver  
1
  • Ortholog Compara
Isoform  Iso 1   Cellular response to oxidative stressdefinition[GO:0034599]  
1
  • UniProtKB
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
1
  • Ortholog Compara
Cobalt ion transportdefinition[GO:0006824]  
2
  • UniProtKB
  • Ortholog Compara
Copper ion import into celldefinition[GO:1902861] silver  
1
  • Ortholog Compara
Copper ion transmembrane transportdefinition[GO:0035434]  
2
  • GOC
  • Ortholog Compara
Copper ion transportdefinition[GO:0006825]  
1
  • BHF-UCL
Dendrite morphogenesisdefinition[GO:0048813] silver  
1
  • Ortholog Compara
Isoform  Iso 1 but not isoform  Iso 2   Detection of oxygendefinition[GO:0003032]  
1
  • UniProtKB
Erythrocyte developmentdefinition[GO:0048821] silver  
1
  • Ortholog Compara
Ferrous iron importdefinition[GO:0070627]  
2
  • UniProtKB
  • Ortholog Compara
Ferrous iron transmembrane transportdefinition[GO:1903874]  
5
  • GOC
  • Ortholog Compara
Ferrous iron transportdefinition[GO:0015684]  
3
  • UniProtKB
  • BHF-UCL
Heme biosynthetic processdefinition[GO:0006783] silver  
1
  • Ortholog Compara
Hydrogen ion transmembrane transportdefinition[GO:1902600] silver  
1
  • Ortholog Compara
Lead ion transportdefinition[GO:0015692]  
2
  • UniProtKB
  • BHF-UCL
Learning or memorydefinition[GO:0007611] silver  
1
  • Ortholog Compara
Manganese ion transmembrane transportdefinition[GO:0071421]  
3
  • GOC
  • Ortholog Compara
Manganese ion transportdefinition[GO:0006828]  
2
  • BHF-UCL
  • UniProtKB
Multicellular organismal iron ion homeostasisdefinition[GO:0060586]  
1
  • BHF-UCL
Nickel cation transmembrane transportdefinition[GO:0035444]  
2
  • GOC
  • Ortholog Compara
Isoforms  Iso 1 and Iso 3   Nickel cation transportdefinition[GO:0015675]  
1
  • UniProtKB
Response to cadmium iondefinition[GO:0046686] silver  
1
  • Ortholog Compara
Isoforms  Iso 2 and Iso 1   Response to hypoxiadefinition[GO:0001666]  
1
  • UniProtKB
Isoforms  Iso 1 , Iso 3 , Iso 4 and Iso 5 but not isoform  Iso 2   Response to iron iondefinition[GO:0010039]  
5
  • UniProtKB
  • BHF-UCL
Response to lead iondefinition[GO:0010288] silver  
1
  • Ortholog Compara
Response to manganese iondefinition[GO:0010042] silver  
1
  • Ortholog Compara
Isoform  Iso 1   Vanadium ion transportdefinition[GO:0015676]  
1
  • GOC
Isoform  Iso 1   Zinc II ion transmembrane transportdefinition[GO:0071577]  
1
  • GOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+4891  
Mineral absorption  hsa04978+4891  
According to Reactome, this protein belongs to the following pathways:
Iron uptake and transport  REACT_25060  
Metal ion SLC transporters  REACT_20547  
Note 
NRAMP2-mediated iron uptake is markedly stimulated by nifedipine in a concentration-dependent manner.  
1
  • UniProtKB
 

Biophysicochemical properties

Dependence
pH Optimum pH is 5.5-6.5 for Fe(2+) uptake.

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Iron transport  definition   [KW-0410]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DMT1
GenomeRNAi: 4891
PRO: PR:P49281