SLC11A2 - Natural resistance-associated macrophage protein 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SLC11A2 »  Natural resistance-associated macrophage protein 2  (NRAMP 2)
 
Protein also known as:  Solute carrier family 11 member 2.
Gene name:  SLC11A2
Family name: NRAMP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 71 5
GENE REF ISO

Function

 show evidences
Overview 
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the metal ion (mn(2+)-iron) transporter (nramp) family  2.A.55.2.1  
GO molecular function 
Cadmium ion bindingdefinition[GO:0046870] silver  
  • IEAOrtholog Compara
Cadmium ion transmembrane transporter activitydefinition[GO:0015086]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Not Isoform  Iso 3   Calcium ion transmembrane transporter activitydefinition[GO:0015085]  
1
  • IDAUniProtKB
Not Isoform  Iso 3   Chromium ion transmembrane transporter activitydefinition[GO:0070835]  
1
  • IDAUniProtKB
Cobalt ion bindingdefinition[GO:0050897] silver  
  • IEAOrtholog Compara
Cobalt ion transmembrane transporter activitydefinition[GO:0015087]  
1
  • IDAUniProtKB
  • IEAOrtholog Compara
Copper ion bindingdefinition[GO:0005507] silver  
  • IEAOrtholog Compara
Copper ion transmembrane transporter activitydefinition[GO:0005375]  
1
  • IDABHF-UCL
Ferrous iron transmembrane transporter activitydefinition[GO:0015093]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Hydrogen ion transmembrane transporter activitydefinition[GO:0015078] silver  
  • IEAOrtholog Compara
Isoforms  Iso 2 and Iso 1   Inorganic cation transmembrane transporter activitydefinition[GO:0022890]  
1
  • IGIUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAOrtholog Compara
Lead ion transmembrane transporter activitydefinition[GO:0015094]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Manganese ion bindingdefinition[GO:0030145] silver  
  • IEAOrtholog Compara
Manganese ion transmembrane transporter activitydefinition[GO:0005384]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Nickel cation bindingdefinition[GO:0016151] silver  
  • IEAOrtholog Compara
Nickel cation transmembrane transporter activitydefinition[GO:0015099]  
1
  • IDAUniProtKB
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Solute:hydrogen symporter activitydefinition[GO:0015295]  
1
  • IDAUniProtKB
Isoforms  Iso 1 and Iso 3   Vanadium ion transmembrane transporter activitydefinition[GO:0015100]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAOrtholog Compara
Isoform  Iso 1 but not isoform  Iso 3   Zinc ion transmembrane transporter activitydefinition[GO:0005385]  
1
  • IDAUniProtKB
GO biological process 
Isoform  Iso 1   Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IDAUniProtKB
Cadmium ion transmembrane transportdefinition[GO:0070574]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Cellular response to hypoxiadefinition[GO:0071456] silver  
  • IEAOrtholog Compara
Cellular response to iron iondefinition[GO:0071281] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Cellular response to oxidative stressdefinition[GO:0034599]  
1
  • IDAUniProtKB
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
  • IEAOrtholog Compara
Isoforms  Iso 1 and Iso 3   Cobalt ion transportdefinition[GO:0006824]  
1
  • IDAUniProtKB
Copper ion transportdefinition[GO:0006825]  
1
  • IDABHF-UCL
Dendrite morphogenesisdefinition[GO:0048813] silver  
  • IEAOrtholog Compara
Isoform  Iso 1 but not isoform  Iso 2   Detection of oxygendefinition[GO:0003032]  
1
  • IEPUniProtKB
Erythrocyte developmentdefinition[GO:0048821] silver  
  • IEAOrtholog Compara
Ferrous iron importdefinition[GO:0070627]  
1
  • IDAUniProtKB
  • IEAOrtholog Compara
Ferrous iron transportdefinition[GO:0015684]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Heme biosynthetic processdefinition[GO:0006783] silver  
  • IEAOrtholog Compara
Lead ion transportdefinition[GO:0015692]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Learning or memorydefinition[GO:0007611] silver  
  • IEAOrtholog Compara
Isoforms  Iso 1 and Iso 3   Manganese ion transmembrane transportdefinition[GO:0071421]  
1
  • IDAGOC
Manganese ion transportdefinition[GO:0006828]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Multicellular organismal iron ion homeostasisdefinition[GO:0060586]  
1
  • IMPBHF-UCL
Isoforms  Iso 1 and Iso 3   Nickel cation transmembrane transportdefinition[GO:0035444]  
1
  • IDAGOC
Isoforms  Iso 1 and Iso 3   Nickel cation transportdefinition[GO:0015675]  
1
  • IDAUniProtKB
Response to cadmium iondefinition[GO:0046686] silver  
  • IEAOrtholog Compara
Isoforms  Iso 2 and Iso 1   Response to hypoxiadefinition[GO:0001666]  
1
  • IEPUniProtKB
Isoforms  Iso 1 , Iso 3 , Iso 4 and Iso 5 but not isoform  Iso 2   Response to iron iondefinition[GO:0010039]  
5
  • IEPUniProtKB
  • IEPBHF-UCL
Response to lead iondefinition[GO:0010288] silver  
  • IEAOrtholog Compara
Response to manganese iondefinition[GO:0010042] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Vanadium ion transportdefinition[GO:0015676]  
1
  • IDAGOC
Isoform  Iso 1   Zinc ion transmembrane transportdefinition[GO:0071577]  
1
  • IDAGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+4891  
Mineral absorption  hsa04978+4891  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Note 
NRAMP2-mediated iron uptake is markedly stimulated by nifedipine in a concentration-dependent manner.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Dependence
pH Optimum pH is 5.5-6.5 for Fe(2+) uptake.

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Iron transport  definition   [KW-0410]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DMT1
GenomeRNAi: 4891
PRO: PR:P49281