ALDH7A1 - Alpha-aminoadipic semialdehyde dehydrogenase - human protein (Function)
 
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Protein
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ALDH7A1 »  Alpha-aminoadipic semialdehyde dehydrogenase   [ EC 1.2.1.31 ]  (Alpha-AASA dehydrogenase)
 
Protein also known as:  Delta1-piperideine-6-carboxylate dehydrogenase (P6c dehydrogenase).
Gene name:  ALDH7A1
Family name: Aldehyde dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.  
2
  • CuratedUniProtKB
GO molecular function 
Aldehyde dehydrogenase (NAD) activitydefinition[GO:0004029]  
  • ISSOrtholog Curator
Betaine-aldehyde dehydrogenase activitydefinition[GO:0008802]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Cellular aldehyde metabolic processdefinition[GO:0006081]  
  • ISSOrtholog Curator
Glycine betaine biosynthetic process from cholinedefinition[GO:0019285]  
  • IEAUniPathway
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Sensory perception of sounddefinition[GO:0007605]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.2.1.31: (S)-2-amino-6-oxohexanoate + NAD(P)(+) + H(2)O L-2-aminoadipate + NAD(P)H.  
  • CuratedUniProtKB
EC 1.2.1.8: Betaine aldehyde + NAD(+) + H(2)O betaine + NADH.  
  • CuratedUniProtKB
EC 1.2.1.3: An aldehyde + NAD(+) + H(2)O a carboxylate + NADH.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+501  
Ascorbate and aldarate metabolism  hsa00053+501  
beta-Alanine metabolism  hsa00410+501  
Fatty acid metabolism  hsa00071+501  
Glycerolipid metabolism  hsa00561+501  
Glycine, serine and threonine metabolism  hsa00260+501  
Glycolysis / Gluconeogenesis  hsa00010+501  
Histidine metabolism  hsa00340+501  
Lysine biosynthesis  hsa00300+501  
Lysine degradation  hsa00310+501  
Metabolic pathways  hsa01100+501  
Propanoate metabolism  hsa00640+501  
Pyruvate metabolism  hsa00620+501  
Tryptophan metabolism  hsa00380+501  
Valine, leucine and isoleucine degradation  hsa00280+501  
According to Reactome, this protein belongs to the following pathway:
Lysine catabolism  REACT_1298  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 647.4 uM for propanal
KM 530.2 uM for benzaldehyde
KM 39.1 uM for hexanal
KM 7374.3 uM for glyceraldehyde
KM 41.1 uM for betaine aldehyde
KM 169 uM for L-2-aminoadipate 6-semialdehyde
KM 28.5 uM for nonanal
KM 17.5 uM for octanal
KM 5.3 uM for trans-2-nonenal
Vmax 72.3 nmol/min/mg enzyme toward octanal
Vmax 276.2 nmol/min/mg enzyme toward L-2-aminoadipate 6-semialdehyde
Vmax 69.9 nmol/min/mg enzyme toward propanal
Vmax 101.4 nmol/min/mg enzyme toward betaine aldehyde
Vmax 364.9 nmol/min/mg enzyme toward nonanal
Vmax 243.3 nmol/min/mg enzyme toward hexanal
Vmax 125.2 nmol/min/mg enzyme toward benzaldehyde
Vmax 34.9 nmol/min/mg enzyme toward trans-2-nonenal
Vmax 174 nmol/min/mg enzyme toward glyceraldehyde

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P49419
Other
GeneWiki: ALDH7A1
GenomeRNAi: 501
PRO: PR:P49419