GLUD2 - Glutamate dehydrogenase 2, mitochondrial - human protein (Function)
 
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GLUD2 »  Glutamate dehydrogenase 2, mitochondrial   [ EC 1.4.1.3 ]  (GDH 2)
 
Gene name:  GLUD2
Entry whose protein(s) existence is based on evidence at protein level
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1 34 1
GENE REF ISO

Function

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Overview 
Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.  
  • CuratedUniProtKB
GO molecular function 
ADP bindingdefinition[GO:0043531]  
1
  • IDABHF-UCL
Glutamate dehydrogenase (NAD+) activitydefinition[GO:0004352]  
2
  • IDAUniProtKB
Glutamate dehydrogenase [NAD(P)+] activitydefinition[GO:0004353]  
1
  • IDABHF-UCL
GTP bindingdefinition[GO:0005525]  
1
  • IDABHF-UCL
Leucine bindingdefinition[GO:0070728]  
1
  • IDABHF-UCL
GO biological process 
Glutamate biosynthetic processdefinition[GO:0006537]  
1
  • IDABHF-UCL
Glutamate catabolic processdefinition[GO:0006538]  
1
  • IDABHF-UCL
Glutamate metabolic processdefinition[GO:0006536]  
1
  • IDAUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.4.1.3: L-glutamate + H(2)O + NAD(P)(+) 2-oxoglutarate + NH(3) + NAD(P)H.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+2747  
Arginine and proline metabolism  hsa00330+2747  
D-Glutamine and D-glutamate metabolism  hsa00471+2747  
Metabolic pathways  hsa01100+2747  
Nitrogen metabolism  hsa00910+2747  
Proximal tubule bicarbonate reclamation  hsa04964+2747  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P49448
Other
GeneWiki: GLUD2
GenomeRNAi: 2747
PRO: PR:P49448