AARS - Alanine--tRNA ligase, cytoplasmic - human protein (Function)
 
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AARS »  Alanine--tRNA ligase, cytoplasmic   [ EC 6.1.1.7 ]
 
Protein also known as:  Renal carcinoma antigen NY-REN-42.
Gene name:  AARS
Entry whose protein(s) existence is based on evidence at protein level
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1 37 1
GENE REF ISO

Function

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Overview 
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Alanine-tRNA ligase activitydefinition[GO:0004813]  
  • IEAEC 2 GO
Amino acid bindingdefinition[GO:0016597] silver  
  • IEAOrtholog Compara
Aminoacyl-tRNA editing activitydefinition[GO:0002161] silver  
  • IEAOrtholog Compara
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
tRNA bindingdefinition[GO:0000049] silver  
  • IEAOrtholog Compara
GO biological process 
Alanyl-tRNA aminoacylationdefinition[GO:0006419] silver  
  • IEAOrtholog Compara
Cerebellar Purkinje cell layer developmentdefinition[GO:0021680] silver  
  • IEAOrtholog Compara
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968] silver  
  • IEAOrtholog Compara
Hair follicle developmentdefinition[GO:0001942] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
  • IEAOrtholog Compara
Protein foldingdefinition[GO:0006457] silver  
  • IEAOrtholog Compara
Response to amino aciddefinition[GO:0043200] silver  
  • IEAOrtholog Compara
tRNA modificationdefinition[GO:0006400] silver  
  • IEAOrtholog Compara
tRNA processingdefinition[GO:0008033]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.1.1.7: ATP + L-alanine + tRNA(Ala) AMP + diphosphate + L-alanyl-tRNA(Ala).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (Potential).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Aminoacyl-tRNA biosynthesis  hsa00970+16  
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Aminoacyl-tRNA synthetase  definition   [KW-0030]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 16
PRO: PR:P49588