CARS - Cysteine--tRNA ligase, cytoplasmic - human protein (Function)
 
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Protein
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References

 
CARS »  Cysteine--tRNA ligase, cytoplasmic   [ EC 6.1.1.16 ]
 
Protein also known as:  Cysteinyl-tRNA synthetase (CysRS).
Gene name:  CARS
Entry whose protein(s) existence is based on evidence at protein level
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1 30 3
GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Cysteine-tRNA ligase activitydefinition[GO:0004817]  
3
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
2
  • IMPUniProtKB
tRNA bindingdefinition[GO:0000049]  
3
  • IMPUniProtKB
GO biological process 
Cysteinyl-tRNA aminoacylationdefinition[GO:0006423]  
3
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.1.1.16: ATP + L-cysteine + tRNA(Cys) AMP + diphosphate + L-cysteinyl-tRNA(Cys).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Aminoacyl-tRNA biosynthesis  hsa00970+833  
According to Reactome, this protein belongs to the following pathway:
Cytosolic tRNA aminoacylation  REACT_15306  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Aminoacyl-tRNA synthetase  definition   [KW-0030]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 833
PRO: PR:P49589