PPM1F - Protein phosphatase 1F - human protein (Function)
 
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PPM1F »  Protein phosphatase 1F
 
Gene name:  PPM1F
Family name: PP2C
Entry whose protein(s) existence is based on evidence at protein level
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1 23 1
GENE REF ISO

Function

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Overview 
Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.  
  • CuratedUniProtKB
GO molecular function 
Calmodulin-dependent protein phosphatase activitydefinition[GO:0033192]  
2
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Phosphatase activitydefinition[GO:0016791]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIUniProtKB
  • IPIIntAct
Protein serine/threonine phosphatase activitydefinition[GO:0004722]  
4
  • IDAUniProtKB
GO biological process 
Cellular response to drugdefinition[GO:0035690]  
1
  • IDAUniProtKB
Histone dephosphorylationdefinition[GO:0016576] silver  
  • IEAOrtholog Compara
Intrinsic apoptotic signaling pathwaydefinition[GO:0097193]  
1
  • IDAUniProtKB
Negative regulation of peptidyl-serine phosphorylationdefinition[GO:0033137]  
1
  • IDAUniProtKB
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • IDAUniProtKB
Negative regulation of protein kinase activity by regulation of protein phosphorylationdefinition[GO:0044387]  
1
  • IDAUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IMPUniProtKB
Peptidyl-threonine dephosphorylationdefinition[GO:0035970]  
4
  • IDAUniProtKB
Positive regulation of cell-substrate adhesiondefinition[GO:0010811]  
1
  • IMPUniProtKB
Positive regulation of chemotaxisdefinition[GO:0050921]  
1
  • IMPUniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043280]  
1
  • IDAUniProtKB
Positive regulation of epithelial cell migrationdefinition[GO:0010634]  
1
  • IMPUniProtKB
Positive regulation of focal adhesion assemblydefinition[GO:0051894]  
1
  • IMPUniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IMPUniProtKB
Positive regulation of growthdefinition[GO:0045927]  
1
  • IMPUniProtKB
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
2
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.16: [a protein]-serine/threonine phosphate + H(2)O [a protein]-serine/threonine + phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium or manganese ions per subunit (By similarity).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPM1F
GenomeRNAi: 9647
PRO: PR:P49593