CASP4 - Caspase-4 - human protein (Function)
 
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CASP4 »  Caspase-4   [ EC 3.4.22.57 ]  (CASP-4)
 
Protein also known as:  Protease ICH-2. Cleaved into:  Caspase-4 subunit 1; Caspase-4 subunit 2.
Gene name:  CASP4
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 2
GENE REF ISO

Function

 show evidences
Overview 
Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1.  
2
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IEAInterPro 2 GO
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of apoptotic processdefinition[GO:0042981] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.57: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by the effector protein NleF that is produced by pathogenic E.coli; this inhibits apoptosis.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P49662
Other
GenomeRNAi: 837
PRO: PR:P49662