CSNK1E - Casein kinase I isoform epsilon - human protein (Function)
 
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CSNK1E »  Casein kinase I isoform epsilon
 
Gene name:  CSNK1E
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
10
  • IPIIntAct
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
  • ISSOrtholog Curator
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDAUniProtKB
GO biological process 
Cellular protein localizationdefinition[GO:0034613] silver  
  • IEAOrtholog Compara
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
DNA repairdefinition[GO:0006281]  
1
  • TASPINC
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178] silver  
  • IEAOrtholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263] silver  
  • IEAOrtholog Compara
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Regulation of circadian rhythmdefinition[GO:0042752]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Phosphorylation leads to a decrease of the catalytic activity.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Circadian rhythm - mammal  hsa04710+1454  
Hedgehog signaling pathway  hsa04340+1454  
Wnt signaling pathway  hsa04310+1454  
According to Reactome, this protein belongs to the following pathways:
Circadian Clock  REACT_24941  
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
WNT mediated activation of DVL  REACT_200668  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CSNK1E
GenomeRNAi: 1454
PRO: PR:P49674
Chemistry
GuidetoPHARMACOLOGY: 1998