CSNK1E - Casein kinase I isoform epsilon - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CSNK1E »  Casein kinase I isoform epsilon   [ EC 2.7.11.1 ]  (CKIe)
 
Gene name:  CSNK1E
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 78 1
GENE REF ISO

Function

 show evidences
Overview 
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
10
  • IPIIntAct
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
  • ISSOrtholog Curator
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDAUniProtKB
GO biological process 
Cellular protein localizationdefinition[GO:0034613] silver  
  • IEAOrtholog Compara
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
DNA repairdefinition[GO:0006281]  
1
  • TASPINC
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178] silver  
  • IEAOrtholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263] silver  
  • IEAOrtholog Compara
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Regulation of circadian rhythmdefinition[GO:0042752]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Phosphorylation leads to a decrease of the catalytic activity.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Circadian rhythm - mammal  hsa04710+1454  
Hedgehog signaling pathway  hsa04340+1454  
Wnt signaling pathway  hsa04310+1454  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Circadian Clock  REACT_24941  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CSNK1E
GenomeRNAi: 1454
PRO: PR:P49674
Chemistry
GuidetoPHARMACOLOGY: 1998