CXCR3 - C-X-C chemokine receptor type 3 - human protein (Function)
 
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CXCR3 »  C-X-C chemokine receptor type 3  (CXC-R3)
 
Protein also known as:  Interferon-inducible protein 10 receptor (IP-10 receptor); CD antigen CD183.
Gene name:  CXCR3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 188 3
GENE REF ISO

Function

 show evidences
Overview 
Isoform  Iso 1   Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed12782716). Binds to CCL21. Probably promotes cell chemotaxis response.  
2
  • UniProtKB
Isoform  Iso 2   Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.  
2
  • UniProtKB
Isoform  Iso 3   Mediates the activity of CXCL11.  
1
  • UniProtKB
GO molecular function 
Isoforms  Iso 1 and Iso 2   C-X-C chemokine bindingdefinition[GO:0019958]  
1
  • UniProtKB
C-X-C chemokine receptor activitydefinition[GO:0016494] silver  
1
  • Ortholog Compara
Chemokine bindingdefinition[GO:0019956]  
1
  • BHF-UCL
Chemokine receptor activitydefinition[GO:0004950]  
1
  • PINC
Isoforms  Iso 1 and Iso 2   Receptor activitydefinition[GO:0004872]  
1
  • UniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB KW
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB KW
Calcium-mediated signalingdefinition[GO:0019722] silver  
1
  • Ortholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • PINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • BHF-UCL
Isoforms  Iso 1 and Iso 2   Chemokine (C-C motif) ligand 11 productiondefinition[GO:0071954]  
1
  • UniProtKB
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
3
  • GOC
  • InterPro 2 GO
  • Ortholog Compara
Chemotaxisdefinition[GO:0006935]  
1
  • PINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
2
  • UniProtKB
  • UniProtKB KW
Inflammatory responsedefinition[GO:0006954] silver  
1
  • InterPro 2 GO
Movement of cell or subcellular componentdefinition[GO:0006928]  
1
  • PINC
Isoform  Iso 2   Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • UniProtKB
Isoform  Iso 2   Negative regulation of endothelial cell proliferationdefinition[GO:0001937]  
1
  • UniProtKB
Isoform  Iso 1   Negative regulation of execution phase of apoptosisdefinition[GO:1900118]  
1
  • UniProtKB
Isoform  Iso 1   Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • UniProtKB
Isoform  Iso 2   Positive regulation of cAMP metabolic processdefinition[GO:0030816]  
1
  • UniProtKB
Isoform  Iso 2   Positive regulation of cAMP-mediated signalingdefinition[GO:0043950]  
1
  • UniProtKB
Isoform  Iso 1   Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Isoform  Iso 1   Positive regulation of chemotaxisdefinition[GO:0050921]  
1
  • UniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
1
  • Ortholog Compara
Isoform  Iso 2   Positive regulation of execution phase of apoptosisdefinition[GO:1900119]  
1
  • UniProtKB
Isoform  Iso 1   Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281]  
1
  • UniProtKB
Isoform  Iso 2   Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Regulation of leukocyte migrationdefinition[GO:0002685] silver  
1
  • InterPro 2 GO
T cell chemotaxisdefinition[GO:0010818] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2833  
Cytokine-cytokine receptor interaction  hsa04060+2833  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  R-HSA-380108  
G alpha (i) signalling events  R-HSA-418594  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Apoptosis  definition   [KW-0053]
Chemotaxis  definition   [KW-0145]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CXCR3
GenomeRNAi: 2833
PRO: PR:P49682
Chemistry
GuidetoPHARMACOLOGY: 70