CXCR3 - C-X-C chemokine receptor type 3 - human protein (Function)
 
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CXCR3 »  C-X-C chemokine receptor type 3  (CXC-R3)
 
Protein also known as:  Interferon-inducible protein 10 receptor (IP-10 receptor); CD antigen CD183.
Gene name:  CXCR3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 171 3
GENE REF ISO

Function

 show evidences
GO molecular function 
Isoforms  Iso 1 and Iso 2   C-X-C chemokine bindingdefinition[GO:0019958]  
1
  • IDAUniProtKB
C-X-C chemokine receptor activitydefinition[GO:0016494] silver  
  • IEAOrtholog Compara
Chemokine bindingdefinition[GO:0019956]  
1
  • IPIBHF-UCL
Chemokine receptor activitydefinition[GO:0004950]  
1
  • TASPINC
Isoforms  Iso 1 and Iso 2   Receptor activitydefinition[GO:0004872]  
1
  • IDAUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Calcium-mediated signalingdefinition[GO:0019722] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • IDABHF-UCL
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Isoforms  Iso 1 and Iso 2   Chemokine (C-C motif) ligand 11 productiondefinition[GO:0071954]  
1
  • IDAUniProtKB
Chemokine-mediated signaling pathwaydefinition[GO:0070098] silver  
  • IEAOrtholog Compara
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IMPUniProtKB
  • IEAUniProtKB KW
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAInterPro 2 GO
Isoform  Iso 2   Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • IDAUniProtKB
Isoform  Iso 2   Negative regulation of endothelial cell proliferationdefinition[GO:0001937]  
1
  • IDAUniProtKB
Isoform  Iso 1   Negative regulation of execution phase of apoptosisdefinition[GO:1900118]  
1
  • IDAUniProtKB
Isoform  Iso 1   Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IDAUniProtKB
Isoform  Iso 2   Positive regulation of cAMP metabolic processdefinition[GO:0030816]  
1
  • IDAUniProtKB
Isoform  Iso 2   Positive regulation of cAMP-mediated signalingdefinition[GO:0043950]  
1
  • IDAUniProtKB
Isoform  Iso 1   Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAUniProtKB
Isoform  Iso 1   Positive regulation of chemotaxisdefinition[GO:0050921]  
1
  • IDAUniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Isoform  Iso 2   Positive regulation of execution phase of apoptosisdefinition[GO:1900119]  
1
  • IDAUniProtKB
Isoform  Iso 1   Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281]  
1
  • IMPUniProtKB
Isoform  Iso 2   Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Regulation of leukocyte migrationdefinition[GO:0002685] silver  
  • IEAInterPro 2 GO
T cell chemotaxisdefinition[GO:0010818] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2833  
Cytokine-cytokine receptor interaction  hsa04060+2833  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Apoptosis  definition   [KW-0053]
Chemotaxis  definition   [KW-0145]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CXCR3
GenomeRNAi: 2833
PRO: PR:P49682
Chemistry
GuidetoPHARMACOLOGY: 70