CEBPA - CCAAT/enhancer-binding protein alpha - human protein (Function)
 
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CEBPA »  CCAAT/enhancer-binding protein alpha
 
Gene name:  CEBPA
Family name: bZIP » C/EBP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
HMG box domain bindingdefinition[GO:0071837] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • NASUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDAUniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Acute-phase responsedefinition[GO:0006953] silver  
  • IEAOrtholog Compara
Brown fat cell differentiationdefinition[GO:0050873] silver  
  • IEAOrtholog Compara
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Cellular response to lithium iondefinition[GO:0071285] silver  
  • IEAOrtholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
  • IEAOrtholog Compara
Cholesterol metabolic processdefinition[GO:0008203] silver  
  • IEAOrtholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • NASUniProtKB
Embryonic placenta developmentdefinition[GO:0001892] silver  
  • IEAOrtholog Compara
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Inner ear developmentdefinition[GO:0048839] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Macrophage differentiationdefinition[GO:0030225] silver  
  • IEAOrtholog Compara
Mitochondrion organizationdefinition[GO:0007005] silver  
  • IEAOrtholog Compara
Myeloid cell differentiationdefinition[GO:0030099]  
1
  • NASUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Positive regulation of fat cell differentiationdefinition[GO:0045600] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase III promoterdefinition[GO:0045945]  
1
  • IDAUniProtKB
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to vitamin B2definition[GO:0033274] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
2
  • IDAUniProtKB
Urea cycledefinition[GO:0000050] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
White fat cell differentiationdefinition[GO:0050872] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+1050  
Pathways in cancer  hsa05200+1050  
According to Reactome, this protein belongs to the following pathway:
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CEBPA
GenomeRNAi: 1050
PRO: PR:P49715