CEBPA - CCAAT/enhancer-binding protein alpha - human protein (Function)
 
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CEBPA »  CCAAT/enhancer-binding protein alpha  (C/EBP alpha)
 
Gene name:  CEBPA
Family name: bZIP » C/EBP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity).  
5
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • PINC
HMG box domain bindingdefinition[GO:0071837] silver  
1
  • Ortholog Compara
Kinase bindingdefinition[GO:0019900]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • Ortholog Curator
Isoform  Iso 4   RNA polymerase I regulatory region DNA bindingdefinition[GO:0001013]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
3
  • UniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • Ortholog Curator
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • UniProtKB
GO biological process 
Acute-phase responsedefinition[GO:0006953] silver  
1
  • Ortholog Compara
Brown fat cell differentiationdefinition[GO:0050873] silver  
1
  • Ortholog Compara
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Cellular response to lithium iondefinition[GO:0071285] silver  
1
  • Ortholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
1
  • Ortholog Compara
Cholesterol metabolic processdefinition[GO:0008203] silver  
1
  • Ortholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • UniProtKB
Embryonic placenta developmentdefinition[GO:0001892] silver  
1
  • Ortholog Compara
Fat cell differentiationdefinition[GO:0045444]  
1
  • Ortholog Curator
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • PINC
Glucose homeostasisdefinition[GO:0042593]  
1
  • Ortholog Curator
Granulocyte differentiationdefinition[GO:0030851]  
1
  • Ortholog Curator
Inner ear developmentdefinition[GO:0048839] silver  
1
  • Ortholog Compara
Lipid homeostasisdefinition[GO:0055088]  
1
  • Ortholog Curator
Liver developmentdefinition[GO:0001889]  
1
  • Ortholog Curator
Lung developmentdefinition[GO:0030324]  
1
  • Ortholog Curator
Macrophage differentiationdefinition[GO:0030225] silver  
1
  • Ortholog Compara
Mitochondrion organizationdefinition[GO:0007005] silver  
1
  • Ortholog Compara
Myeloid cell differentiationdefinition[GO:0030099]  
1
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
2
  • UniProtKB
  • Ortholog Curator
Negative regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045736]  
1
  • ParkinsonsUK-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • Ortholog Curator
Organ regenerationdefinition[GO:0031100] silver  
1
  • Ortholog Compara
Positive regulation of fat cell differentiationdefinition[GO:0045600] silver  
1
  • Ortholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
1
  • Ortholog Compara
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
1
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • MGI
Positive regulation of transcription from RNA polymerase III promoterdefinition[GO:0045945]  
1
  • UniProtKB
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to vitamin B2definition[GO:0033274] silver  
1
  • Ortholog Compara
Isoform  Iso 4   Transcription from RNA polymerase I promoterdefinition[GO:0006360]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
2
  • UniProtKB
Urea cycledefinition[GO:0000050] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
White fat cell differentiationdefinition[GO:0050872] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+1050  
Pathways in cancer  hsa05200+1050  
According to Reactome, this protein belongs to the following pathway:
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CEBPA
GenomeRNAi: 1050
PRO: PR:P49715