COMP - Cartilage oligomeric matrix protein - human protein (Function)
 
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COMP »  Cartilage oligomeric matrix protein  (COMP)
 
Protein also known as:  Thrombospondin-5 (TSP5).
Gene name:  COMP
Family name: Thrombospondin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 102 2
GENE REF ISO

Function

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Overview 
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).  
1
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
2
  • UniProtKB
Collagen bindingdefinition[GO:0005518]  
1
  • UniProtKB
Extracellular matrix structural constituentdefinition[GO:0005201] silver  
1
  • InterPro 2 GO
Heparan sulfate proteoglycan bindingdefinition[GO:0043395]  
1
  • UniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB
Protease bindingdefinition[GO:0002020]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • UniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB KW
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Growth plate cartilage developmentdefinition[GO:0003417] silver  
1
  • Ortholog Compara
Limb developmentdefinition[GO:0060173]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Organ morphogenesisdefinition[GO:0009887]  
1
  • PINC
Skeletal system developmentdefinition[GO:0001501]  
1
  • PINC
Enzymatic activity 
It requires the following cofactor
 Ca(2+) : Binds 11-14 calcium ions per subunit.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
ECM-receptor interaction  hsa04512+1311  
Focal adhesion  hsa04510+1311  
Malaria  hsa05144+1311  
Phagosome  hsa04145+1311  
TGF-beta signaling pathway  hsa04350+1311  
According to Reactome, this protein belongs to the following pathways:
ECM proteoglycans  REACT_163906  
Integrin cell surface interactions  REACT_13552  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links