ACADVL - Very long-chain specific acyl-CoA dehydrogenase, mitochondrial - human protein (Function)
 
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Protein
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References

 
ACADVL »  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial   [ EC 1.3.8.9 ]  (VLCAD)
 
Gene name:  ACADVL
Family name: Acyl-CoA dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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1 45 3
GENE REF ISO

Function

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Overview 
Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.  
1
  • CuratedUniProtKB
GO molecular function 
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
Long-chain-acyl-CoA dehydrogenase activitydefinition[GO:0004466]  
1
  • TASPINC
GO biological process 
Energy derivation by oxidation of organic compoundsdefinition[GO:0015980]  
1
  • TASPINC
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • IEPUniProtKB
Fatty acid beta-oxidation using acyl-CoA dehydrogenasedefinition[GO:0033539]  
  • ISSOrtholog Curator
Negative regulation of fatty acid biosynthetic processdefinition[GO:0045717]  
  • ISSOrtholog Curator
Negative regulation of fatty acid oxidationdefinition[GO:0046322]  
  • ISSOrtholog Curator
Regulation of cholesterol metabolic processdefinition[GO:0090181]  
  • ISSOrtholog Curator
Temperature homeostasisdefinition[GO:0001659]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.8.9: A very-long-chain acyl-CoA + electron-transfer flavoprotein a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
FAD.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fatty acid metabolism  hsa00071+37  
Metabolic pathways  hsa01100+37  
According to Reactome, this protein belongs to the following pathways:
Beta oxidation of palmitoyl-CoA to myristoyl-CoA  REACT_2025  
XBP1(S) activates chaperone genes  REACT_18273  
 
More information is available from:
Note 
A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 37
PRO: PR:P49748