CLK1 - Dual specificity protein kinase CLK1 - human protein (Function)
 
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CLK1 »  Dual specificity protein kinase CLK1   [ EC 2.7.12.1 ]
 
Protein also known as:  CDC-like kinase 1.
Gene name:  CLK1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
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  • PINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • UniProtKB
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
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  • EC 2 GO
GO biological process 
Cell proliferationdefinition[GO:0008283]  
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  • PINC
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
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  • Ortholog Compara
Peptidyl-threonine phosphorylationdefinition[GO:0018107] silver  
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  • Ortholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108] silver  
1
  • Ortholog Compara
Protein autophosphorylationdefinition[GO:0046777] silver  
1
  • Ortholog Compara
Regulation of RNA splicingdefinition[GO:0043484]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.1: ATP + a protein ADP + a phosphoprotein.  
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  • UniProtKB
It is regulated in the following manner
Regulates splicing of its own pre-mRNA according to its kinase activity; increased expression of the catalytically active form influences splicing to generate the catalytically inactive splicing variant lacking the kinase domain. Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins (By similarity).  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Legionellosis  hsa05134+1195  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CLK1
GenomeRNAi: 1195
PRO: PR:P49759
Chemistry
GuidetoPHARMACOLOGY: 1990