EIF2B2 - Translation initiation factor eIF-2B subunit beta - human protein (Function)
 
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EIF2B2 »  Translation initiation factor eIF-2B subunit beta
 
Protein also known as:  eIF-2B GDP-GTP exchange factor subunit beta.
Gene name:  EIF2B2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
GTP bindingdefinition[GO:0005525]  
1
  • UniProtKB
Contributes to guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Not  S-methyl-5-thioribose-1-phosphate isomerase activitydefinition[GO:0046523]  
1
  • RefGenome
Contributes to translation initiation factor activitydefinition[GO:0003743]  
1
  • UniProtKB
GO biological process 
Cellular response to stimulusdefinition[GO:0051716]  
1
  • UniProtKB
Central nervous system developmentdefinition[GO:0007417]  
1
  • UniProtKB
Not  L-methionine biosynthetic process from methylthioadenosinedefinition[GO:0019509]  
1
  • RefGenome
Myelinationdefinition[GO:0042552]  
1
  • UniProtKB
Oligodendrocyte developmentdefinition[GO:0014003]  
1
  • UniProtKB
Ovarian follicle developmentdefinition[GO:0001541]  
1
  • UniProtKB
Positive regulation of GTPase activitydefinition[GO:0043547]  
2
  • GOC
Regulation of translational initiationdefinition[GO:0006446]  
2
  • UniProtKB
  • RefGenome
Response to glucosedefinition[GO:0009749]  
1
  • Ortholog Curator
Response to heatdefinition[GO:0009408]  
2
  • UniProtKB
  • Ortholog Curator
Response to peptide hormonedefinition[GO:0043434]  
1
  • Ortholog Curator
Translational initiationdefinition[GO:0006413]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA transport  hsa03013+8892  
According to Reactome, this protein belongs to the following pathway:
Recycling of eIF2:GDP  REACT_1815  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Initiation factor  definition   [KW-0396]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EIF2B2
GenomeRNAi: 8892
PRO: PR:P49770