RGS4 - Regulator of G-protein signaling 4 - human protein (Function)
 
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RGS4 »  Regulator of G-protein signaling 4  (RGP4)
 
Gene name:  RGS4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.  
  • CuratedUniProtKB
GO molecular function 
Calmodulin bindingdefinition[GO:0005516]  
1
  • TASPINC
G-protein alpha-subunit bindingdefinition[GO:0001965] silver  
  • IEAOrtholog Compara
GTPase activator activitydefinition[GO:0005096] silver  
  • IBARefGenome
GO biological process 
Inactivation of MAPK activitydefinition[GO:0000188]  
1
  • TASPINC
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
1
  • TASPINC
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
  • IEAInterPro 2 GO
 

Keywords

Molecular function 
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RGS4
GenomeRNAi: 5999
PRO: PR:P49798