RGS7 - Regulator of G-protein signaling 7 - human protein (Function)
 
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RGS7 »  Regulator of G-protein signaling 7  (RGS7)
 
Gene name:  RGS7
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity).  
1
  • UniProtKB
GO molecular function 
G-protein beta-subunit bindingdefinition[GO:0031681]  
1
  • UniProtKB
GTPase activator activitydefinition[GO:0005096]  
1
  • RefGenome
Signal transducer activitydefinition[GO:0004871] silver  
1
  • InterPro 2 GO
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186] silver  
1
  • InterPro 2 GO
Intracellular signal transductiondefinition[GO:0035556] silver  
1
  • InterPro 2 GO
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • RefGenome
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
1
  • InterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
G alpha (i) signalling events  REACT_19231  
 

Keywords

Molecular function 
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RGS7
GenomeRNAi: 6000
PRO: PR:P49802