KLK7 - Kallikrein-7 - human protein (Function)
 
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Protein
Gene
References

 
KLK7 »  Kallikrein-7   [ EC 3.4.21.117 ]
 
Protein also known as:  Stratum corneum chymotryptic enzyme.
Gene name:  KLK7
Family name: Peptidase S1 » Kallikrein
Entry whose protein(s) existence is based on evidence at protein level
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1 56 2
GENE REF ISO

Function

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Overview 
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.  
1
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • TASPINC
GO biological process 
Epidermis developmentdefinition[GO:0008544]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.117: Cleavage of proteins with aromatic side chains in the P1 position.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KLK7
GenomeRNAi: 5650
PRO: PR:P49862