CAMP - Cathelicidin antimicrobial peptide - human protein (Function)
 
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CAMP »  Cathelicidin antimicrobial peptide
 
Protein also known as:  18 kDa cationic antimicrobial protein (CAP-18). Cleaved into:  Antibacterial protein FALL-39; Antibacterial protein LL-37.
Gene name:  CAMP
Family name: Cathelicidin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the cathelicidin (cathelicidin) family  1.C.33.1.10  
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • IntAct
GO biological process 
Antibacterial humoral responsedefinition[GO:0019731]  
1
  • UniProtKB
Cellular response to interleukin-1definition[GO:0071347] silver  
1
  • Ortholog Compara
Cellular response to interleukin-6definition[GO:0071354] silver  
1
  • Ortholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
1
  • Ortholog Compara
Cellular response to peptidoglycandefinition[GO:0071224] silver  
1
  • Ortholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
1
  • Ortholog Compara
Defense response to bacteriumdefinition[GO:0042742]  
1
  • PINC
Defense response to Gram-negative bacteriumdefinition[GO:0050829] silver  
1
  • Ortholog Compara
Defense response to Gram-positive bacteriumdefinition[GO:0050830]  
1
  • UniProtKB
Innate immune response in mucosadefinition[GO:0002227]  
1
  • UniProtKB
Killing by host of symbiont cellsdefinition[GO:0051873]  
1
  • MGI
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
1
  • Ortholog Compara
Negative regulation of growth of symbiont on or near host surfacedefinition[GO:0044140]  
1
  • MGI
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Salivary secretion  hsa04970+820  
Tuberculosis  hsa05152+820  
According to Reactome, this protein belongs to the following pathway:
Phagosomal maturation (early endosomal stage)  REACT_121256  
Caution 
PubMed:11238224 sequence was incorrectly assigned to originate from M.mulatta.  
1
  • UniProtKB
 

Keywords

Molecular function 
Antibiotic  definition   [KW-0044]
Antimicrobial  definition   [KW-0929]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cathelicidin
GenomeRNAi: 820
PRO: PR:P49913