GMPS - GMP synthase [glutamine-hydrolyzing] - human protein (Function)
 
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GMPS »  GMP synthase [glutamine-hydrolyzing]   [ EC 6.3.5.2 ]
 
Protein also known as:  Glutamine amidotransferase.
Gene name:  GMPS
Entry whose protein(s) existence is based on evidence at protein level
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1 28 2
GENE REF ISO

Function

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Overview 
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
GMP synthase (glutamine-hydrolyzing) activitydefinition[GO:0003922]  
  • IEAEC 2 GO
GMP synthase activitydefinition[GO:0003921]  
1
  • TASPINC
Pyrophosphatase activitydefinition[GO:0016462] silver  
  • IEAInterPro 2 GO
GO biological process 
Glutamine metabolic processdefinition[GO:0006541]  
  • IEAUniProtKB KW
Purine nucleobase biosynthetic processdefinition[GO:0009113]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.5.2: ATP + XMP + L-glutamine + H(2)O AMP + diphosphate + GMP + L-glutamate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Drug metabolism - other enzymes  hsa00983+8833  
Metabolic pathways  hsa01100+8833  
Purine metabolism  hsa00230+8833  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
GMP biosynthesis  definition   [KW-0332]
Purine biosynthesis  definition   [KW-0658]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GMP_synthase
GenomeRNAi: 8833
PRO: PR:P49915