LIG3 - DNA ligase 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
LIG3 »  DNA ligase 3   [ EC 6.5.1.1 ]
 
Protein also known as:  Polydeoxyribonucleotide synthase [ATP] 3.
Gene name:  LIG3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 61 2
GENE REF ISO

Function

 show evidences
Overview 
Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
DNA ligase (ATP) activitydefinition[GO:0003910] silver  
  • IBARefGenome
DNA ligase activitydefinition[GO:0003909]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Base-excision repair, DNA ligationdefinition[GO:0006288] silver  
  • IEAOrtholog Compara
Cell divisiondefinition[GO:0051301]  
  • IEAUniProtKB KW
Double-strand break repair via nonhomologous end joiningdefinition[GO:0006303] silver  
  • IEAOrtholog Compara
Lagging strand elongationdefinition[GO:0006273] silver  
  • IBARefGenome
Mitochondrial DNA repairdefinition[GO:0043504] silver  
  • IEAOrtholog Compara
Negative regulation of DNA recombinationdefinition[GO:0045910] silver  
  • IEAOrtholog Compara
Nucleotide-excision repairdefinition[GO:0006289] silver  
  • IBARefGenome
Reciprocal meiotic recombinationdefinition[GO:0007131]  
1
  • TASPINC
Spermatogenesisdefinition[GO:0007283]  
1
  • TASPINC
Not  V(D)J recombinationdefinition[GO:0033151]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.5.1.1: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) AMP + diphosphate + (deoxyribonucleotide)(n+m).  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Base excision repair  hsa03410+3980  
According to Reactome, this protein belongs to the following pathway:
DNA Repair  REACT_216  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
DNA replication  definition   [KW-0235]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LIG3
GenomeRNAi: 3980
PRO: PR:P49916