LIG3 - DNA ligase 3 - human protein (Function)
 
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Protein
Gene
References

 
LIG3 »  DNA ligase 3   [ EC 6.5.1.1 ]
 
Protein also known as:  Polydeoxyribonucleotide synthase [ATP] 3.
Gene name:  LIG3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 86 4
GENE REF ISO

Function

 show evidences
Overview 
Isoform  Iso 1   Is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed10207110, PubMed24674627).  
3
  • UniProtKB
Isoform  Iso 3   Functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
DNA bindingdefinition[GO:0003677] silver  
1
  • InterPro 2 GO
DNA ligase (ATP) activitydefinition[GO:0003910]  
3
  • BHF-UCL
  • EC 2 GO
DNA ligase activitydefinition[GO:0003909]  
2
  • BHF-UCL
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • AgBase
  • UniProtKB
  • BHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Base-excision repair, DNA ligationdefinition[GO:0006288]  
2
  • BHF-UCL
Cell cycledefinition[GO:0007049]  
1
  • UniProtKB KW
Cell divisiondefinition[GO:0051301]  
1
  • UniProtKB KW
DNA biosynthetic processdefinition[GO:0071897] silver  
1
  • InterPro 2 GO
Isoform  Iso 3   DNA ligationdefinition[GO:0006266]  
1
  • BHF-UCL
Double-strand break repairdefinition[GO:0006302]  
1
  • BHF-UCL
Isoform  Iso 3   Double-strand break repair via alternative nonhomologous end joiningdefinition[GO:0097681]  
1
  • BHF-UCL
Double-strand break repair via nonhomologous end joiningdefinition[GO:0006303] silver  
1
  • Ortholog Compara
Not  Lagging strand elongationdefinition[GO:0006273]  
1
  • RefGenome
Mitochondrial DNA repairdefinition[GO:0043504]  
2
  • BHF-UCL
  • Ortholog Compara
Isoform  Iso 1   Mitochondrion organizationdefinition[GO:0007005]  
1
  • BHF-UCL
Negative regulation of DNA recombinationdefinition[GO:0045910] silver  
1
  • Ortholog Compara
Negative regulation of mitochondrial DNA replicationdefinition[GO:0090298] silver  
1
  • CACAO
Not  V(D)J recombinationdefinition[GO:0033151]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.5.1.1: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) AMP + diphosphate + (deoxyribonucleotide)(n+m).  
4
  • UniProtKB
  • PROSITE-ProRule
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Base excision repair  hsa03410+3980  
According to Reactome, this protein belongs to the following pathway:
Resolution of AP sites via the single-nucleotide replacement pathway  REACT_933  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
DNA replication  definition   [KW-0235]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LIG3
GenomeRNAi: 3980
PRO: PR:P49916