CDKN1C - Cyclin-dependent kinase inhibitor 1C - human protein (Function)
 
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CDKN1C »  Cyclin-dependent kinase inhibitor 1C
 
Protein also known as:  Cyclin-dependent kinase inhibitor p57.
Gene name:  CDKN1C
Family name: CDI
Entry whose protein(s) existence is based on evidence at protein level
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1 108 2
GENE REF ISO

Function

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Overview 
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.  
  • CuratedUniProtKB
GO molecular function 
Cyclin-dependent protein serine/threonine kinase inhibitor activitydefinition[GO:0004861] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Cell cycle arrestdefinition[GO:0007050] silver  
  • IEAInterPro 2 GO
Mitotic G1 phasedefinition[GO:0000080]  
1
  • TASPINC
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
1
  • IMPBHF-UCL
Negative regulation of kinase activitydefinition[GO:0033673]  
1
  • IDAUniProtKB
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • IDAUniProtKB
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • TASGOC
Negative regulation of protein serine/threonine kinase activitydefinition[GO:0071901]  
1
  • TASGOC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Neuron maturationdefinition[GO:0042551] silver  
  • IEAOrtholog Compara
Placenta developmentdefinition[GO:0001890] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IGIUniProtKB
Positive regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030511]  
1
  • IMPBHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0000079]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cell cycle  hsa04110+1028  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Molecular function 
Protein kinase inhibitor  definition   [KW-0649]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links